Immunogenic necroptosis in liver diseases: mechanisms and therapeutic potential

Necroptosis has received increasing attention and is extensively studied as a recently discovered mode of cell death distinct from necrosis and apoptosis. It is a programmed cell death with a necrotic morphology that occurs in various biological processes, including inflammation, immune response, em...

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Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2023-11, Vol.101 (11), p.1355-1363
Main Authors: Ye, Zirui, Zhang, Nana, Lei, Hong, Yao, Huimin, Fu, Jingya, Zhang, Nan, Xu, Lexuan, Zhou, Guxiang, Liu, Zhijun, Lv, Yi
Format: Article
Language:English
Subjects:
Apoptosis
Apoptosis - physiology
Biomedical and Life Sciences
Biomedicine
Cell death
Cytology
Embryogenesis
Homeostasis
Human Genetics
Humans
Immune response
Immunogenicity
Internal Medicine
Liver diseases
Liver Diseases - etiology
Liver Diseases - metabolism
Liver Diseases - therapy
Molecular Medicine
Necroptosis
Necrosis
Protein Kinases - metabolism
Receptor-Interacting Protein Serine-Threonine Kinases - metabolism
Review
Signal transduction
Therapeutic targets
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Summary:Necroptosis has received increasing attention and is extensively studied as a recently discovered mode of cell death distinct from necrosis and apoptosis. It is a programmed cell death with a necrotic morphology that occurs in various biological processes, including inflammation, immune response, embryonic development, and metabolic abnormalities. Necroptosis is indispensable in maintaining tissue homeostasis in vivo and closely correlates with the occurrence and development of various diseases. First, we outlined the etiology of necroptosis and how it affects the onset and development of prevalent liver diseases in this review. Additionally, we reviewed the therapeutic strategy by targeting the necroptosis pathway in related liver diseases. We conclude that the necroptosis signaling pathway is critical in the physiological control of liver diseases’ onset, progression, and prognosis. It will likely be used as a therapeutic target in the future. Further research is required to determine the mechanisms governing the necroptosis signaling pathway and the effector molecules.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-023-02363-y