β-glucuronidase as a biomarker for assessing the exposure to anticholinergic pesticides: A meta-analysis

• Published in: Environmental toxicology and pharmacology 2023-10, Vol.103, p.104279-104279, Article 104279
• Main Authors: Serafín-Fabian, Jesús Isimar, Elena Moreno-Godínez, Ma, Flores-Alfaro, Eugenia, Parra-Rojas, Isela, Rojas-García, Aurora Elizabeth, Campos-Viguri, Gabriela Elizabeth, Cahua-Pablo, José Ángel, Ramírez-Vargas, Marco Antonio
• Format: Article
• Language: English
• Subjects: Carbamates; Human biomonitoring; Occupational exposure; Organophosphates; Pesticide poisoning; β-glucuronidase
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2023.104279

The human exposure to anticholinergic pesticides has been associated with the development of various diseases. Therefore, several biomarkers have been proposed for biomonitoring human exposure to anticholinergic pesticides. This work evaluated the effect of human exposure to anticholinergic pesticides on β-glucuronidase (GUSB) levels. A systematic review was performed using PubMed, Web of Science, Scopus, and EBSCO databases up to December 2021. The statistical analysis employed standardized mean differences and meta-regression. And the trial sequential analysis was performed. Nine studies were included. A monotonic relationship was observed between poisoning severity and GUSB. Furthermore, BuChE levels were correlated with GUSB levels. The results indicated that GUSB levels could be used as a possible diagnosis biomarker in poisoning related to anticholinergic pesticide exposure. However, the use of GUSB to assess the chronic exposure to anticholinergic pesticides could be only performed in recent exposure (≈ 7 days after last exposure).