Microenvironment in acute myeloid leukemia: focus on senescence mechanisms, therapeutic interactions, and future directions

•Bone marrow niche is a dynamic structure that plays a main role in leukemogenesis.•Early cellular senescence severely alters the microenvironment.•Microenvironment is an essential component of stem cell transplant engraftment. Acute myeloid leukemia (AML) is a disease with a dismal prognosis, mainl...

Full description

Saved in:
Bibliographic Details
Published in:Experimental hematology 2024-01, Vol.129, p.104118-104118, Article 104118
Main Authors: Guarnera, Luca, Santinelli, Enrico, Galossi, Elisa, Cristiano, Antonio, Fabiani, Emiliano, Falconi, Giulia, Voso, Maria Teresa
Format: Article
Language:English
Subjects:
Aged
Bone Marrow - pathology
Hematopoietic Stem Cell Transplantation
Humans
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - therapy
Quality of Life
Tumor Microenvironment
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Bone marrow niche is a dynamic structure that plays a main role in leukemogenesis.•Early cellular senescence severely alters the microenvironment.•Microenvironment is an essential component of stem cell transplant engraftment. Acute myeloid leukemia (AML) is a disease with a dismal prognosis, mainly affecting the elderly. In recent years, new drugs have improved life expectancy and quality of life, and a better understanding of the genetic-molecular nature of the disease has shed light on previously unknown aspects of leukemogenesis. In parallel, increasing attention has been attracted to the complex interactions between cells and soluble factors in the bone marrow (BM) environment, collectively known as the microenvironment. In this review, we discuss the central role of the microenvironment in physiologic and pathologic hematopoiesis and the mechanisms of senescence, considered a fundamental protective mechanism against the proliferation of damaged and pretumoral cells. The microenvironment also represents a fertile ground for the development of myeloid malignancies, and the leukemic niche significantly interacts with drugs commonly used in AML treatment. Finally, we focus on the role of the microenvironment in the engraftment and complications of allogeneic hematopoietic stem cell transplantation, the only curative option in a conspicuous proportion of patients.
ISSN:0301-472X
1873-2399
DOI:10.1016/j.exphem.2023.09.005