Chitosan-gentamicin conjugate attenuates heat stress-induced intestinal barrier injury via the TLR4/STAT6/MYLK signaling pathway: In vitro and in vivo studies

Heat stress (HS) has a negative impact on animal health. A modified chitosan-gentamicin conjugate (CS-GT) was prepared to investigate its potential protective effects and mechanism of action on heat stress-induced intestinal mucosa injury in IPEC-J2 cells and mouse 3D intestinal organs in a mouse mo...

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Bibliographic Details
Published in:Carbohydrate polymers 2023-12, Vol.321, p.121279-121279, Article 121279
Main Authors: Niu, Xueting, Hu, Canying, Chen, Shengwei, Wen, Jiaying, Liu, Xiaoxi, Yong, Yanhong, Yu, Zhichao, Ma, Xingbin, Li, Chengpeng, Warda, Mohamad, Abd El-Aty, A.M., Gooneratne, Ravi, Ju, Xianghong
Format: Article
Language:English
Subjects:
CS-GT
Heat stress
Intestinal barrier injury
TLR4/STAT6/MYLK
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Summary:Heat stress (HS) has a negative impact on animal health. A modified chitosan-gentamicin conjugate (CS-GT) was prepared to investigate its potential protective effects and mechanism of action on heat stress-induced intestinal mucosa injury in IPEC-J2 cells and mouse 3D intestinal organs in a mouse model. CS-GT significantly (P 
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2023.121279