Unilateral anterior capsulotomy combined with deep brain stimulation for Parkinson's disease psychosis and motor dysfunctions

• Published in: Progress in neuro-psychopharmacology & biological psychiatry 2024-01, Vol.128, p.110865-110865, Article 110865
• Main Authors: Wang, Fang, Dai, Lulin, Pan, Yixin, Huang, Peng, Zhang, Chencheng, Sun, Bomin, Li, Dianyou
• Format: Article
• Language: English
• Subjects: Anterior capsulotomy; Deep brain stimulation; Parkinson's disease; Parkinson's disease psychosis
• ISSN: 0278-5846; 1878-4216
• DOI: 10.1016/j.pnpbp.2023.110865

Psychosis is a frequent and debilitating non-motor symptom of Parkinson's disease (PD). This study aimed to evaluate the availability of unilateral anterior capsulotomy combined with subthalamic nucleus deep brain stimulation (STN-DBS) in managing advanced PD patients comorbid with psychosis. Five advanced PD patients with psychosis who had been treated with unilateral anterior capsulotomy combined with bilateral STN-DBS were assessed. The positive subscore of the Positive and Negative Syndrome Scale (PANSS) and the Unified Parkinson's Disease Rating Scale III (UPDRS-III) were used to assess the efficacy parameter of psychosis and the improved motor symptoms, respectively. The quality of life (QoL) was accessed by an 8-item Parkinson's disease Questionnaire (PDQ-8). Clinical outcome assessments were performed at baseline and follow-ups after one or two years. Significant improvement was observed in PD patients during follow-up after the combined treatment. The positive subscore of PANSS improved by 13.4 (5.7) (mean (SD), p = 0.006). Item P1 (delusions) and Item P3 (hallucinations) of the PANSS improved by 5.0 (0.71) (p