Role of Nuclear Factor-Kappa B Activation and Inflammatory Biomarkers in Critically Ill Children

Mortality prediction is important for cautious monitoring and optimal management of critically ill children. The serum cytokine levels are elevated early in critical illness before the physiological parameters are deranged. This cross-sectional descriptive study included the critically ill children...

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Published in:Indian journal of pediatrics 2024-10, Vol.91 (10), p.1075-1077
Main Authors: Reddy, Akula Sai Sneha, Rao, Swathi Sunil, D Shenoy, Vijaya, Shetty, Shilpa
Format: Article
Language:English
Subjects:
Biomarkers - blood
Child
Child, Preschool
Clinical Brief
Critical Illness
Cross-Sectional Studies
Female
Gynecology
Humans
Infant
Inflammation - blood
Intensive Care Units, Pediatric
Interleukin-6 - blood
Male
Medicine
Medicine & Public Health
NF-kappa B - blood
Pediatrics
Prognosis
Severity of Illness Index
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container_issue 10
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container_title Indian journal of pediatrics
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creator Reddy, Akula Sai Sneha
Rao, Swathi Sunil
D Shenoy, Vijaya
Shetty, Shilpa
description Mortality prediction is important for cautious monitoring and optimal management of critically ill children. The serum cytokine levels are elevated early in critical illness before the physiological parameters are deranged. This cross-sectional descriptive study included the critically ill children admitted in intensive care unit. Serial serum levels of IL-6, NF-κB and PELOD 2 scoring were measured and compared in 45 children (40 survivors, 5 non-survivors). The median IL-6 levels at 24 h and 72 h were significantly high in non-survivors when compared to survivors [median (IQR) = 1122 (1305) pg/ml vs. 564.39 (153) pg/ml and 1263 (626) pg/ml vs. 82 (191) pg/ml respectively; p  
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The serum cytokine levels are elevated early in critical illness before the physiological parameters are deranged. This cross-sectional descriptive study included the critically ill children admitted in intensive care unit. Serial serum levels of IL-6, NF-κB and PELOD 2 scoring were measured and compared in 45 children (40 survivors, 5 non-survivors). The median IL-6 levels at 24 h and 72 h were significantly high in non-survivors when compared to survivors [median (IQR) = 1122 (1305) pg/ml vs. 564.39 (153) pg/ml and 1263 (626) pg/ml vs. 82 (191) pg/ml respectively; p  &lt;0.0001)]. There was an increasing trend of IL-6 in non-survivors when compared to the survivors. The NF-κB values were comparable. The IL-6 levels correlated well with the illness severity. 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subjects Biomarkers - blood
Child
Child, Preschool
Clinical Brief
Critical Illness
Cross-Sectional Studies
Female
Gynecology
Humans
Infant
Inflammation - blood
Intensive Care Units, Pediatric
Interleukin-6 - blood
Male
Medicine
Medicine & Public Health
NF-kappa B - blood
Pediatrics
Prognosis
Severity of Illness Index
title Role of Nuclear Factor-Kappa B Activation and Inflammatory Biomarkers in Critically Ill Children
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