Unveiling the role of cerebellar alterations in the autonomic nervous system: a systematic review of autonomic dysfunction in spinocerebellar ataxias

Background Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and diffe...

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Bibliographic Details
Published in:Journal of neurology 2023-12, Vol.270 (12), p.5756-5772
Main Authors: Urbini, Nicole, Siciliano, Libera, Olivito, Giusy, Leggio, Maria
Format: Article
Language:English
Subjects:
Autonomic Nervous System
Cerebellum
Dysautonomia
Humans
Literature reviews
Medicine
Medicine & Public Health
Nervous system
Neurology
Neuroradiology
Neurosciences
Primary Dysautonomias
Review
Spinocerebellar ataxia
Spinocerebellar Ataxias - genetics
Systematic review
Citations: Items that this one cites
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Summary:Background Autonomic dysfunctions are prevalent in several cerebellar disorders, but they have not been systematically investigated in spinocerebellar ataxias (SCAs). Studies investigating autonomic deficits in SCAs are fragmented, with each one focusing on different autonomic dysfunctions and different SCA subtypes. Methods Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, we conducted a systematic review of the literature to assess the presence of autonomic dysfunctions in various SCAs. PubMed served as the primary database, and the Rayyan web application was employed for study screening. Results We identified 46 articles investigating at least one autonomic function in patients with SCA. The results were analyzed and categorized based on the genetic subtype of SCA, thereby characterizing the specific autonomic deficits associated with each subtype. Conclusion This review confirms the presence of autonomic dysfunctions in various genetic subtypes of SCA, underscoring the cerebellum's role in the autonomic nervous system (ANS). It also emphasizes the importance of investigating these functions in clinical practice.
ISSN:0340-5354
1432-1459
DOI:10.1007/s00415-023-11993-8