OCT-A evaluation of the retinal and choroidal structures of patients with a history of radiotherapy due to nasopharyngeal carcinoma

•Radiation retinopathy is a serious sight-threatening condition.•Early diagnosis of radiation retinopathy is very important.•Microvascular architecture of retina is affected by radiotherapy in the early period.•OCT-A is a promising tool for the early diagnosis of radiation retinopathy. To perform th...

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Bibliographic Details
Published in:Photodiagnosis and photodynamic therapy 2023-12, Vol.44, p.103812-103812, Article 103812
Main Authors: Sabancı, Şenol, Arslan, İbrahim, Küçük, Mehmet Fatih, Yavuz, Sibel, Erol, Muhammet Kazım, Çeçen, Sare
Format: Article
Language:English
Subjects:
Optical coherence tomography angiography
Radiation retinopathy
Retinal microvasculature
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Summary:•Radiation retinopathy is a serious sight-threatening condition.•Early diagnosis of radiation retinopathy is very important.•Microvascular architecture of retina is affected by radiotherapy in the early period.•OCT-A is a promising tool for the early diagnosis of radiation retinopathy. To perform the optical coherence tomography angiography (OCT-A) evaluation of the microvascular structures of the retina and choroidal tissue in asymptomatic patients who received radiotherapy for nasopharyngeal carcinoma and to compare the results to those of healthy individuals. Ophthalmological examinations were performed in all asymptomatic patients without vascular or systemic diseases, or fundus findings who had received radiotherapy at least two years earlier. Then, OCT-A scans were obtained. Foveal, parafoveal, and whole retinal thicknesses, vessel densities in the superficial and deep capillary plexuses, subfoveal choroidal thickness, the non-flow area in the superficial capillary plexus, and the choriocapillaris flow area were measured and compared to the values of the healthy control group. The radiotherapy group had significantly lower deep capillary plexus vascular density and subfoveal choroidal thickness values and significantly higher choriocapillaris flow area values compared to the control group. We consider that OCT-A is useful in the early diagnosis of radiation retinopathy that may develop during follow-up in patients with nasopharyngeal carcinoma who have received radiotherapy.
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2023.103812