Breast cancer molecular subtype and relationship with clinicopathological profiles among Vietnamese women: A retrospective study

• Published in: Pathology, research and practice research and practice, 2023-10, Vol.250, p.154819-154819, Article 154819
• Main Authors: Thuc Nguyen, Thi Minh, Dinh Le, Roanh, Nguyen, Chu Van
• Format: Article
• Language: English
• Subjects: Breast cancer; Clinicopathological profiles; Distribution; Molecular subtypes; Relationship
• ISSN: 0344-0338; 1618-0631
• DOI: 10.1016/j.prp.2023.154819

Molecular subtypes play an important role in predicting prognosis and guiding treatment for breast cancer. Having a better knowledge of ethnic molecular features is essential. Determining the distribution of various breast cancer molecular subtypes and investigating the relationship between these subtypes and clinicopathological features. Retrospective data was collected from Hanoi National Cancer Hospital and Bach Mai Hospital that included 274 women diagnosed with invasive breast cancer between January 2017 and June 2019. Patients were categorized into five subtypes according to the 2015 St. Gallen molecular classification. The variables analyzed were molecular subtypes and tumor-related characteristics. To evaluate the relationship between these subtypes and clinicopathological features, a Chi-squared test and Fisher exact test were performed. The most prominent subtype was Luminal A (33.2%), followed by Luminal B/Her2- (19.7%) and Luminal B/Her2 + (17.5%), then HER2 overexpression (16.4%), whereas triple negative was the least popular subtype (13.1%). Particularly, 33.9% of all patients, including the Luminal B/Her2 + and the HER2 overexpressing groups, were Her2 positive. There was a statistically significant difference between molecular subtypes and histological type (p = 0.01), tumor grade (p