Type 2 diabetes and fasting glycemic traits are causal factors of frozen shoulder: a 2-sample Mendelian randomization analysis

The causal relationship between type 2 diabetes (T2D) and frozen shoulder is unclear. This study aims to explore the genetic causal association between T2D and glycemic traits (fasting glucose [FG], fasting insulin [FI], glycated hemoglobin [HbA1c], and 2-hour postprandial glucose [2hGlu]) on frozen...

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Bibliographic Details
Published in:Journal of shoulder and elbow surgery 2024-02, Vol.33 (2), p.399-408
Main Authors: Xu, Tianhao, Xia, Qinghong, Zhang, Lei, Yang, Xiaolong, Fu, Weili
Format: Article
Language:English
Subjects:
2-h postprandial glucose
Bursitis
Diabetes Mellitus, Type 2 - genetics
Fasting
fasting glucose
fasting insulin
Frozen shoulder
Genome-Wide Association Study
Glucose
glycated hemoglobin
Humans
Insulin
Mendelian randomization
Mendelian Randomization Analysis
Polymorphism, Single Nucleotide
type 2 diabetes
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Summary:The causal relationship between type 2 diabetes (T2D) and frozen shoulder is unclear. This study aims to explore the genetic causal association between T2D and glycemic traits (fasting glucose [FG], fasting insulin [FI], glycated hemoglobin [HbA1c], and 2-hour postprandial glucose [2hGlu]) on frozen shoulder. Using 2-sample Mendelian randomization (MR), we analyzed nonconfounded estimates of the effects of T2D and glycemic traits on frozen shoulder. Single-nucleotide polymorphisms (SNPs) strongly associated (P 
ISSN:1058-2746
1532-6500
DOI:10.1016/j.jse.2023.08.006