Resilience Phenotypes and Psychological Functioning among Individuals with Opioid Use Disorder

Opioid use disorder (OUD) is a heterogeneous disorder. However, there is a lack of deep phenotyping investigations focusing on important psychological constructs such as resilience that may impact OUD. The present study aimed to investigate the relationship between trait resilience and the five-fact...

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Bibliographic Details
Published in:Substance use & misuse 2024, Vol.59 (1), p.41-49
Main Authors: Martinez, Suky, Garcia-Romeu, Albert, Perez, Freymon, Jones, Jermaine D
Format: Article
Language:English
Subjects:
Agreeableness
Clinical significance
Cluster analysis
Conscientiousness
Drug abuse
Epigenetics
Extraversion
Five factor model
Humans
Mental depression
Multivariate analysis
Narcotics
Neuroticism
Openness
Opioid-Related Disorders
Opioids
Personality
Personality Disorders - diagnosis
Personality Inventory
Personality traits
Phenotype
Phenotypes
Psychological distress
Psychological functioning
Psychological problems
Resilience
Resilience, Psychological
Stress
Substance use disorder
Symptoms
Variance analysis
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Summary:Opioid use disorder (OUD) is a heterogeneous disorder. However, there is a lack of deep phenotyping investigations focusing on important psychological constructs such as resilience that may impact OUD. The present study aimed to investigate the relationship between trait resilience and the five-factor model of personality (FFM) among individuals with opioid use disorder (OUD). We also explored whether the FFM and trait resilience form specific phenotypes associated with psychological functioning. This secondary analysis of an epigenetic study included participants of African ancestry (  = 72), an understudied population, who met DSM-5 criteria for OUD. Participants completed measures to assess personality traits, trait resilience, current and previous drug use, and psychological functioning (depression, anxiety, and stress). Linear regression revealed a significant relationship between resilience (CD-RISC-25 score) and the FFM, = 0.56, (5,62) = 15.7,
ISSN:1082-6084
1532-2491
1532-2491
DOI:10.1080/10826084.2023.2259450