Decrease of radiation-induced skin reactions in breast cancer patients by preventive application of film dressings—a systematic review

Purpose Radiation-induced skin reactions remain one of the most frequent side effects of adjuvant radiotherapy for breast cancer, which is the most common global malignancy. In individual cases, we observed a decrease in radiation dermatitis under film dressings used for skin marking purposes. There...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2024-02, Vol.200 (2), p.109-122
Main Authors: Kraemer, Judith, Momm, Felix
Format: Article
Language:English
Subjects:
Bandages
Breast
Breast cancer
Breast Neoplasms - radiotherapy
Clinical trials
Dermatitis
Female
Humans
Literature reviews
Medicine
Medicine & Public Health
Neoplasms, Radiation-Induced
Oncology
Polyurethane resins
Polyurethanes
Radiation
Radiation effects
Radiation therapy
Radiodermatitis - etiology
Radiodermatitis - prevention & control
Radiotherapy
Review Article
Side effects
Spanish language
Systematic review
Terminology
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Summary:Purpose Radiation-induced skin reactions remain one of the most frequent side effects of adjuvant radiotherapy for breast cancer, which is the most common global malignancy. In individual cases, we observed a decrease in radiation dermatitis under film dressings used for skin marking purposes. Therefore, we decided to revise the available evidence regarding the prophylactic use of film dressings to reduce radiation dermatitis in breast cancer patients. Methods On 20 March 2023, we conducted a systematic review of literature for randomized controlled trials published in the English, German, French, or Spanish language, available in the PubMed database. Results Of 82 publications, 9 full texts were assessed and 6 randomized controlled trials were included in the final synthesis. Two trials analyzed the application of polyurethane film (Hydrofilm, Paul Hartmann AG, Heidenheim, Germany), the other four of silicone-based polyurethane film (Mepitel film, Molnlycke Health Care Limited, Milton Keynes, United Kingdom). The evaluation scales Common Terminology Criteria for Adverse Events (CTCAE), Radiation Therapy Oncology Group (RTOG), and the Radiation-Induced Skin Reaction Assessment Scale (RISRAS) were used for assessment. All six trials, with a total of 788 patients yielding data for analysis, demonstrate a significant decrease in radiation-induced skin reactions by use of the film (mainly p  
ISSN:0179-7158
1439-099X
1439-099X
DOI:10.1007/s00066-023-02151-0