A reactive matrix for in situ chemical derivatisation and specific detection of cis -diol compounds by matrix-assisted laser desorption/ionisation mass spectrometry

Analysis of cis -diol compounds is essential, because they play important roles in cosmetics, food, pharmaceuticals, and living organisms. Herein, we describe the development of a matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) method to analyse cis -diol compounds. In this...

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Bibliographic Details
Published in:Analyst (London) 2023-10, Vol.148 (21), p.5402-5406
Main Authors: Chen, Jiajing, Huang, Huan, Ouyang, Dan, Lin, Jiali, Chen, Zhuling, Cai, Zongwei, Lin, Zian
Format: Article
Language:English
Subjects:
Alcohols
Cosmetics
Desorption
Food
Ionization
Lasers
Mass spectrometry
Polyols
Reagents
Scientific imaging
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Summary:Analysis of cis -diol compounds is essential, because they play important roles in cosmetics, food, pharmaceuticals, and living organisms. Herein, we describe the development of a matrix-assisted laser desorption/ionisation mass spectrometry (MALDI-MS) method to analyse cis -diol compounds. In this method, a 6-borono-1-methylquinoline-1-ium (BMQI) reactive matrix was designed for in situ derivatisation of cis -diol compounds based on the boronate affinity interaction between boronic acid and cis -diol groups. Compared to traditional commercial matrices and other boronic acid reagents, BMQI can significantly accelerate the desorption/ionisation process, improve reproducibility, exhibit free background interference, and enhance signal intensity in the analysis of various cis -diol compounds even for amounts as low as 1 nmol. The BMQI-assisted laser desorption/ionisation mass spectrometry (LDI-MS) was successfully applied to the rapid screening and identification of sugar alcohols in different sugar-free foods. This work provides an alternative method to the LDI-MS analysis of cis -diol-containing molecules, and the method can be extended to other food samples and biofluids.
ISSN:0003-2654
1364-5528
DOI:10.1039/d3an01400b