Theoretical basis for controlling minimal tumor temperature during interstitial conductive heat therapy

A description is given of the simulation of steady-state intratumoral temperatures achieved by a simple modality of local heat therapy: interstitial treatment with parallel arrays of warmed, conductive heating elements. During conductive heating power is directly deposited only in the interstitial p...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1990-07, Vol.37 (7), p.662-672
Main Authors: Babbs, C.F., Fearnot, N.E., Marchosky, J.A., Moran, C.J., Jones, J.T., Plantenga, T.D.
Format: Article
Language:English
Subjects:
Biological and medical sciences
Computational modeling
Computer Simulation
Computerized, statistical medical data processing and models in biomedicine
Heat treatment
Heating
Hyperthermia, Induced
Medical sciences
Medical treatment
Models, Biological
Neoplasms
Neoplasms - blood supply
Neoplasms - therapy
Probes
Regional Blood Flow - physiology
Software
Steady-state
Temperature control
Temperature distribution
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Summary:A description is given of the simulation of steady-state intratumoral temperatures achieved by a simple modality of local heat therapy: interstitial treatment with parallel arrays of warmed, conductive heating elements. During conductive heating power is directly deposited only in the interstitial probes. Adjacent tissue is warmed by heat conduction. Simulations of interstitial conductive heating involved solution of the bioheat transfer equation on a digital computer using a finite difference model of the treated tissue. The simulations suggest that when the complete temperature distributions for conductive interstitial hyperthermia are examined in detail, substantial uniformity of the temperature distributions is evident. Except for a thin sleeve of tissue surrounding each heating element, a broad, flat central valley of temperature elevation is achieved, with a well-defined minimum temperature, very close to modal and median tissue temperatures. Because probes are inserted directly in tumor tissue, the thin sleeve of overheated tissue would not be expected to cause normal tissue complications. The temperature of the heated probes must be continuously controlled and increased in the face of increased blood flow in order to maintain minimum tumor temperature.< >
ISSN:0018-9294
1558-2531
DOI:10.1109/10.55677