Association of Serotonin Receptor Gene Polymorphisms with Regulatory and Adaptive Capacities of Medical Students

Molecular genetic analysis of polymorphic variants of serotonin receptor genes ( HTR2C and HTR2A ) was performed in 89 healthy medical students and regulatory and adaptive capacities were determined by cardiorespiratory synchronism. The relationship of serotonin receptor gene polymorphisms and the r...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2023-08, Vol.175 (4), p.424-426
Main Authors: Kashina, Yu. V., Cherednik, I. L., Pokrovsky, V. M., Polishchuk, S. V.
Format: Article
Language:English
Subjects:
Adaptation
Adaptation, Psychological
Alleles
Biomedical and Life Sciences
Biomedicine
Cell Biology
Gene polymorphism
Genes
Genetic analysis
Genetic aspects
Genetic polymorphisms
Genetic research
Genotype
Genotype & phenotype
Humans
Internal Medicine
Laboratory Medicine
Medical students
Pathology
Phenols
Physiology
Polymorphism
Polymorphism, Genetic - genetics
Polymorphism, Single Nucleotide - genetics
Receptor, Serotonin, 5-HT2A - genetics
Receptor, Serotonin, 5-HT2C - genetics
Receptors, Serotonin - genetics
Serotonin
Students, Medical
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Description
Summary:Molecular genetic analysis of polymorphic variants of serotonin receptor genes ( HTR2C and HTR2A ) was performed in 89 healthy medical students and regulatory and adaptive capacities were determined by cardiorespiratory synchronism. The relationship of serotonin receptor gene polymorphisms and the regulatory and adaptive capabilities of the body were revealed. The highly active * G allele and * G /* G genotype of the serotonin receptor HTR2C gene and the heterozygous * A /* G genotype of the serotonin receptor HTR2A gene are associated with “good” regulatory and adaptive capacities. The low-active * C allele of the serotonin receptor HTR2C gene is associated with “low” regulatory and adaptive capacities.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-023-05878-z