Protein Kinases and their Inhibitors Implications in Modulating Disease Progression

• Published in: The Protein Journal 2023-12, Vol.42 (6), p.621-632
• Main Authors: Ahsan, Rabiya, Khan, Mohd Muazzam, Mishra, Anuradha, Noor, Gazala, Ahmad, Usama
• Format: Article
• Language: English
• Subjects: Amino acid sequence; Animal Anatomy; B cells; Biochemistry; Bioorganic Chemistry; Cell cycle; Cell differentiation; Chemistry; Chemistry and Materials Science; Drug approval; Drug development; Enzyme inhibitors; Health aspects; Histology; Inhibitors; Kinases; Medical research; Medicine, Experimental; Morphology; Organic Chemistry; Phosphorylation; Protein kinase inhibitors; Protein kinases; Protein turnover; Proteins; Therapeutic targets; Threonine; Tyrosine
• ISSN: 1572-3887; 1875-8355; 1573-4943
• DOI: 10.1007/s10930-023-10159-9

Protein phosphorylation plays an important role in cellular pathways, including cell cycle regulation, metabolism, differentiation and survival. The protein kinase superfamily network consists of 518 members involved in intrinsic or extrinsic interaction processes. Protein kinases are divided into two categories based on their ability to phosphorylate tyrosine, serine, and threonine residues. The complexity of the system implies its vulnerability. Any changes in the pathways of protein kinases may be implicated in pathological processes. Therefore, they are regarded as having an important role in human diseases and represent prospective therapeutic targets. This article provides a review of the protein kinase inhibitors approved by the FDA. Finally, we summarize the mechanism of action of protein kinases, including their role in the development and progression of protein kinase-related roles in various pathological conditions and the future therapeutic potential of protein kinase inhibitors, along with links to protein kinase databases. Further clinical studies aimed at examining the sequence of protein kinase inhibitor availability would better utilize current protein kinase inhibitors in diseases. Additionally, this review may help researchers and biochemists find new potent and selective protein kinase inhibitors and provide more indications for using existing drugs.