Structural insight into EV-A71 3A Protein and Its Interaction with a Peptide Inhibitor

•Our results disclosed a dihelical structure of Enterovirus A71 3A1–57 protein in apo form.•We depicted rigid helices and a unique flexible C-terminus for apo-form 3A1–57.•This study revealed a competitive binding-based molecular mechanism underlying inhibition of dimeric 3A by ER-DRI.

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Bibliographic Details
Published in:Virologica Sinica 2023-12, Vol.38 (6), p.975-979
Main Authors: Liu, Yahui, Lv, Panjing, Wang, Wei, Zhang, Jiahai, Zhou, Xi, Qiu, Yang, Cai, Kun, Zhang, Haoran, Fang, Yuan, Li, Yan
Format: Article
Language:English
Subjects:
Enterovirus A, Human
Enterovirus Infections
Humans
Peptides - pharmacology
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Description
Summary:•Our results disclosed a dihelical structure of Enterovirus A71 3A1–57 protein in apo form.•We depicted rigid helices and a unique flexible C-terminus for apo-form 3A1–57.•This study revealed a competitive binding-based molecular mechanism underlying inhibition of dimeric 3A by ER-DRI.
ISSN:1995-820X
1995-820X
DOI:10.1016/j.virs.2023.09.004