Loading…

Evolutionary characterization and pathogenicity of Getah virus from pigs in Guangdong Province of China

Getah virus (GETV) is an emerging zoonotic virus that can infect humans and many mammals through mosquitoes. In this study, a novel pathogenic GETV strain, GDQY2022, was isolated from a pig farm in Guangdong Province, China. Sequence comparisons and phylogenetic analysis showed that GDQY2022 belongs...

Full description

Saved in:
Bibliographic Details
Published in:Archives of virology 2023-10, Vol.168 (10), p.258-258, Article 258
Main Authors: Pan, Jinghua, Zhang, Haoquan, Chen, Xiuqiao, Zeng, Mengyi, Han, Hui, Guo, Yajing, Li, Jiaming, Luo, Shicheng, Yan, Guangzhi, Chen, Shengnan, Mo, Meilian, Liu, Mingjie, Huang, Liangzong
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Getah virus (GETV) is an emerging zoonotic virus that can infect humans and many mammals through mosquitoes. In this study, a novel pathogenic GETV strain, GDQY2022, was isolated from a pig farm in Guangdong Province, China. Sequence comparisons and phylogenetic analysis showed that GDQY2022 belongs to group III (GIII) and was most closely related to strain HeN202009-2, with 99.78% nucleotide sequence identity. Histopathological examination revealed significant pathological changes, such as widened alveolar septum in the lungs with mild congestion and hemorrhage. Differences in viral load between tissues were assessed by real-time RT-PCR, and significantly higher levels of GETV were found in abdominal lymph nodes and lungs of subclinically and clinically affected pigs ( P  
ISSN:0304-8608
1432-8798
DOI:10.1007/s00705-023-05886-4