Multi-visceral resection for left-sided pancreatic ductal adenocarcinoma: a multicenter retrospective analysis from European countries

• Published in: Langenbeck's archives of surgery 2023-09, Vol.408 (1), p.386-386, Article 386
• Main Authors: Ferrari, Cecilia, Leon, Piera, Falconi, Massimo, Boggi, Ugo, Piardi, Tullio, Sulpice, Laurent, Cavaliere, Davide, Rosso, Edoardo, Chirica, Mircea, Ravazzoni, Ferruccio, Memeo, Riccardo, Pessaux, Patrick, De Blasi, Vito, Mascherini, Matteo, De Cian, Franco, Navarro, Francis, Panaro, Fabrizio
• Format: Article
• Language: English
• Subjects: Abdominal Surgery; Carcinoma, Pancreatic Ductal - pathology; Cardiac Surgery; General Surgery; Humans; Medicine; Medicine & Public Health; Pancreas - surgery; Pancreatectomy - adverse effects; Pancreatic Neoplasms; Pancreatic Neoplasms - pathology; Postoperative Complications - etiology; Retrospective Studies; Thoracic Surgery; Traumatic Surgery; Vascular Surgery
• ISSN: 1435-2451; 1435-2451
• DOI: 10.1007/s00423-023-03110-0

Background Due to delayed diagnosis and a lower surgical indication rate, left-sided pancreatic ductal adenocarcinoma (PDAC) is often associated with a poor prognosis in comparison to pancreatic head tumors. Multi-visceral resections (MVR) associated with distal pancreatectomy could be proposed for patients presenting with locally infiltrating disease. Methods We retrospectively analyzed a multi-centric cohort of left-sided PDAC patients operated on from 2009 to 2020. Thirteen European high-volume HPB centers participated in this study. We analyzed patients who underwent distal pancreatectomy (DP) associated with MVR and compared them to standard DP patients. Results Among 258 patients treated curatively for PDAC of the body and tail, 28 patients successfully underwent MVR. A longer operative time was observed in the MVR group (295 min +/− 74 vs. 250 min +/− 96, p = 0.248). The post-operative complication rate was comparable between the two groups (46.4% in the MVR group vs. 62.2% in the control group, p = 0.108). The incidence of positive margin (R1) was similar between the two groups (28.6% vs. 26.6%; p =0.827). After a median follow-up of 25 (9–111) months, overall survival was comparable between the two groups ( p = 0.519). Conclusions Multi-visceral resection in left-sided pancreatic ductal adenocarcinoma is safe and feasible and should be considered in selected cases as it seems to provide acceptable surgical and oncological outcomes.