Correlation between specific antibody response to wild-type BNT162b2 booster and the risk of breakthrough infection with omicron variants: Impact of household exposure in hospital healthcare workers

•Post-BNT162b2 booster anti-spike IgG titers of healthcare workers were measured.•SARS-CoV-2 exposures and breakthrough infections were recorded during an omicron epidemic.•Post-booster IgG titers were inversely correlated with a SARS-CoV-2 infection risk.•Household exposure was an important source...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine 2023-10, Vol.41 (45), p.6672-6678
Main Authors: Tani, Naoki, Ikematsu, Hideyuki, Goto, Takeyuki, Kondo, Satoko, Gondo, Kei, Fujiyoshi, Naoko, Minami, Junya, Harada, Yukiko, Nagano, Sukehisa, Horiuchi, Takahiko, Kuwano, Hiroyuki, Akashi, Koichi, Shimono, Nobuyuki, Chong, Yong
Format: Article
Language:English
Subjects:
Antibodies
Antibody
antibody formation
Antibody response
Antigens
Body mass index
Breakthrough infection
Close contact
cohort studies
Correlation
COVID-19
COVID-19 vaccines
Diagnostic tests
Drug dosages
Epidemics
Exposure
hazard ratio
Health care
Health risks
health services
Hospitals
Households
Immunoglobulin G
Infections
Interferon
Laboratories
Medical personnel
Occupational exposure
Omicron variant
Proteins
Risk
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccine
Vaccines
γ-Interferon
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:•Post-BNT162b2 booster anti-spike IgG titers of healthcare workers were measured.•SARS-CoV-2 exposures and breakthrough infections were recorded during an omicron epidemic.•Post-booster IgG titers were inversely correlated with a SARS-CoV-2 infection risk.•Household exposure was an important source of SARS-CoV-2 infection for healthcare workers.•Exposure with IgG titers of
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2023.09.051