Prevalence of Pseudomonas aeruginosa and its antibiotic resistance in patients who have received Hematopoietic Stem-Cell Transplantation; A globally Systematic Review

• Published in: Microbial pathogenesis 2023-11, Vol.184, p.106368-106368, Article 106368
• Main Authors: Shakerimoghaddam, Ali, Moghaddam, Arasb Dabbagh, Barghchi, Bita, Pisheh Sanani, Mohammad Ghenaat, Azami, Pouria, Kalmishi, Abolfazl, Sabeghi, Paniz, Motavalli, Farhad, Khomartash, Mehdi Shakouri, Mousavi, Seyyed Hossein, Nikmanesh, Yousef
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - pharmacology; Antibiotic resistance; Cross-Sectional Studies; Drug Resistance, Multiple, Bacterial; Hematopoietic Stem Cell Transplantation; Humans; Prevalence; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - isolation & purification; Pseudomonas Infections - epidemiology
• ISSN: 0882-4010; 1096-1208
• DOI: 10.1016/j.micpath.2023.106368

Gram-negative bacteria are infectious and life-threatening agents after hematopoietic stem cell transplantation (HSCT). So, this study aimed to investigate the prevalence of Pseudomonas aeruginosa and its antibiotic resistance in patients who have received Hematopoietic Stem-Cell Transplantation through a systematic review. The systematic search was done with key words; Pseudomonas aeruginosa, hematopoietic stem cell transplantation from 2000 to the end of July 2023 in Google Scholar and PubMed/Medline, Scopus, and Web of Science. Twelve studies were able to include our study. Quality assessment of studies was done by Appraisal tool for Cross-Sectional Studies. The most of the included studies were conducted as allo-HSCT. Infections such as respiratory infection, urinary infection and bacteremia have occurred. The rate of prevalence with P. aeruginosa has varied between 3 and 100%. The average age of the participants was between 1 and 74 years. The rate of prevalence of P. aeruginosa resistant to several drugs has been reported to be variable, ranging from 20 to 100%. The highest antibiotic resistance was reported against cefotetan (100%), and the lowest was related to tobramycin (1.8%) followed by amikacin, levofloxacin and ciprofloxacin with the prevalence of 16.6%. Our findings showed a high prevalence and antibiotic resistance rate of P. aeruginosa in Hematopoietic stem cell transplantation. Therefore, more serious health measures should be taken in patients after transplantation. •The prevalence rate of P. aeruginosa has varied between 3 and 100% in patients who have received Hematopoietic Stem-Cell Transplantation.•The prevalence of multidrug-resistant (MDR) P. aeruginosa has been reported to be variable, ranging from 20 to 100%.•The highest and the lowest antibiotic resistance were reported against cefotetan (100%), and tobramycin (1.8%), respectively.