Effects of niacin supplementation during in vitro culture on the developmental competence of porcine embryos

Niacin is a water‐soluble vitamin belonging to the vitamin B complex. It has been found to possess various biological activities, including antioxidant and lipid modification capacities. This study aimed to elucidate the effects of niacin treatment in porcine in vitro culture (IVC) medium on embryo...

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Bibliographic Details
Published in:Reproduction in domestic animals 2023-12, Vol.58 (12), p.1685-1694
Main Authors: Almubarak, Areeg, Osman, Rana, Lee, Joohyeong, Yu, Il‐Jeoung, Jeon, Yubyeol
Format: Article
Language:English
Subjects:
Apoptosis
Bcl-2 protein
Cell culture
Cell number
Embryos
Gene expression
Glutathione
in vitro embryos
Lipid metabolism
Lipids
Metabolism
NAD
niacin
Nicotinic acid
Oxidative metabolism
Oxidative stress
PLIN2
Reactive oxygen species
SIRT1
SIRT1 protein
Supplements
Vitamin B
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Summary:Niacin is a water‐soluble vitamin belonging to the vitamin B complex. It has been found to possess various biological activities, including antioxidant and lipid modification capacities. This study aimed to elucidate the effects of niacin treatment in porcine in vitro culture (IVC) medium on embryo developmental competence after parthenogenetic activation. IVC medium was supplemented with different concentrations of niacin (0 [control], 300, 600 and 900 μM). The results showed that embryos cultured in an IVC medium supplemented with 300 and 600 μM niacin had an increased cleavage rate (p 
ISSN:0936-6768
1439-0531
DOI:10.1111/rda.14483