Hair cortisol and endocannabinoid measurement in patients with adrenal incidentalomas: a case–control study

Purpose The role of endocannabinoids (ECs) in the regulation of the hypothalamic-pituitary-adrenocortical axis has already been studied; however, data are scarce in humans. The aim of our study was to analyze EC [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] and cortisol (F) levels in hair sam...

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Published in:Hormones (Athens, Greece) Greece), 2024-03, Vol.23 (1), p.113-120
Main Authors: Mytareli, Chrysoula, Athanasouli, Fani, Andreadaki, Evangelia, Thanasoula, Foteini, Angelousi, Anna
Format: Article
Language:English
Subjects:
Endocrinology
Medicine
Medicine & Public Health
Metabolic Diseases
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Summary:Purpose The role of endocannabinoids (ECs) in the regulation of the hypothalamic-pituitary-adrenocortical axis has already been studied; however, data are scarce in humans. The aim of our study was to analyze EC [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] and cortisol (F) levels in hair samples of patients with adrenal incidentalomas (AIs) in comparison with those found in controls and assess their association with the hormone profile. Methods Forty-four patients with AIs [32 with non-functioning AIs (NFAIs) and 12 with possible autonomous secretion (PACS)] and 44 controls were recruited. Basal and post-1 mg overnight dexamethasone suppression test (ODST) F, adrenocorticotropic hormone, dehydroepiandrosterone sulfate, and 24-h urinary free cortisol were analyzed. After hair collection, EC and F levels were measured by liquid chromatography tandem-mass spectrometry. Results There was no difference between the groups regarding age, sex, and metabolic status. Significantly decreased hair AEA and 2-AG levels were found in patients with AIs compared to controls ( p  
ISSN:1109-3099
2520-8721
DOI:10.1007/s42000-023-00495-x