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Postprandial triglycerides across the aging spectrum: A secondary analysis utilizing an abbreviated fat tolerance test
Elevated postprandial triglycerides are an independent cardiovascular disease risk factor and observed in older adults. However, differences in postprandial triglycerides across the spectrum of adulthood remain unclear. We performed a secondary analysis of six studies where adults (aged 18–84 years;...
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| Published in: | Nutrition, metabolism, and cardiovascular diseases metabolism, and cardiovascular diseases, 2024-01, Vol.34 (1), p.121-125 |
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| container_title | Nutrition, metabolism, and cardiovascular diseases |
| container_volume | 34 |
| creator | Keirns, Bryant H. Sciarrillo, Christina M. Poindexter, Kara L. Dixon, Madison D. Medlin, Austin R. Koemel, Nicholas A. Hart, Samantha M. Geist, Caroline H. Jenkins, Nathaniel D.M. Lucas, Edralin A. Emerson, Sam R. |
| description | Elevated postprandial triglycerides are an independent cardiovascular disease risk factor and observed in older adults. However, differences in postprandial triglycerides across the spectrum of adulthood remain unclear.
We performed a secondary analysis of six studies where adults (aged 18–84 years; N = 155) completed an abbreviated fat tolerance test (9 kcal/kg; 70% fat). Differences in postprandial triglycerides were compared in those ≥50 and |
| doi_str_mv | 10.1016/j.numecd.2023.08.017 |
| format | article |
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We performed a secondary analysis of six studies where adults (aged 18–84 years; N = 155) completed an abbreviated fat tolerance test (9 kcal/kg; 70% fat). Differences in postprandial triglycerides were compared in those ≥50 and <50 years and by decade of life, adjusting for sex and BMI. Compared to those <50 years, participants ≥50 years had higher fasting, 4 h, and Δ triglycerides from baseline (p's < 0.05). When examining triglyceride parameters by decade, no differences were observed for fasting triglycerides, but 50 s, 60 s, and 70s–80 s displayed greater 4 h and Δ triglycerides versus 20 s (p's ≤ 0.001). The frequency of adverse postprandial triglyceride responses (i.e., ≥220 mg/dL) was higher in participants ≥50 versus <50 years (p < 0.01), and in 60 s compared to all other decades (p = 0.01).
Older age was generally associated with higher postprandial triglycerides, with no divergence across the spectrum of older adulthood. In our sample, postprandial triglyceride differences in older and younger adults were driven by those >50 years relative to young adults in their 20 s.
N/A (secondary analysis).
•Fasting triglycerides were similar across all decades of life.•Yet, 50 s, 60 s, 70/80 s had greater postprandial triglyceride responses versus 20 s.•60 s had the highest frequency of adverse postprandial responses vs. other decades.</description><identifier>ISSN: 0939-4753</identifier><identifier>ISSN: 1590-3729</identifier><identifier>EISSN: 1590-3729</identifier><identifier>DOI: 10.1016/j.numecd.2023.08.017</identifier><identifier>PMID: 37788958</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Adult ; Aged ; Aging ; Blood lipids ; Cardiovascular disease ; Fasting ; Humans ; Hypertriglyceridemia - diagnosis ; Hypertriglyceridemia - epidemiology ; Metabolic health ; Older adults ; Postprandial Period - physiology ; Postprandial triglycerides ; Triglycerides ; Young Adult</subject><ispartof>Nutrition, metabolism, and cardiovascular diseases, 2024-01, Vol.34 (1), p.121-125</ispartof><rights>2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University</rights><rights>Copyright © 2023 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Italian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c311t-b36befd1f2d45b1edfd5af9ae10004d7846911aca6c573e16a9d5b41d50220493</cites><orcidid>0000-0002-2354-1534 ; 0000-0001-5837-4820 ; 0000-0002-5463-6894 ; 0000-0001-7439-0871</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37788958$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Keirns, Bryant H.</creatorcontrib><creatorcontrib>Sciarrillo, Christina M.</creatorcontrib><creatorcontrib>Poindexter, Kara L.</creatorcontrib><creatorcontrib>Dixon, Madison D.</creatorcontrib><creatorcontrib>Medlin, Austin R.</creatorcontrib><creatorcontrib>Koemel, Nicholas A.</creatorcontrib><creatorcontrib>Hart, Samantha M.</creatorcontrib><creatorcontrib>Geist, Caroline H.</creatorcontrib><creatorcontrib>Jenkins, Nathaniel D.M.</creatorcontrib><creatorcontrib>Lucas, Edralin A.</creatorcontrib><creatorcontrib>Emerson, Sam R.</creatorcontrib><title>Postprandial triglycerides across the aging spectrum: A secondary analysis utilizing an abbreviated fat tolerance test</title><title>Nutrition, metabolism, and cardiovascular diseases</title><addtitle>Nutr Metab Cardiovasc Dis</addtitle><description>Elevated postprandial triglycerides are an independent cardiovascular disease risk factor and observed in older adults. However, differences in postprandial triglycerides across the spectrum of adulthood remain unclear.
We performed a secondary analysis of six studies where adults (aged 18–84 years; N = 155) completed an abbreviated fat tolerance test (9 kcal/kg; 70% fat). Differences in postprandial triglycerides were compared in those ≥50 and <50 years and by decade of life, adjusting for sex and BMI. Compared to those <50 years, participants ≥50 years had higher fasting, 4 h, and Δ triglycerides from baseline (p's < 0.05). When examining triglyceride parameters by decade, no differences were observed for fasting triglycerides, but 50 s, 60 s, and 70s–80 s displayed greater 4 h and Δ triglycerides versus 20 s (p's ≤ 0.001). The frequency of adverse postprandial triglyceride responses (i.e., ≥220 mg/dL) was higher in participants ≥50 versus <50 years (p < 0.01), and in 60 s compared to all other decades (p = 0.01).
Older age was generally associated with higher postprandial triglycerides, with no divergence across the spectrum of older adulthood. In our sample, postprandial triglyceride differences in older and younger adults were driven by those >50 years relative to young adults in their 20 s.
N/A (secondary analysis).
•Fasting triglycerides were similar across all decades of life.•Yet, 50 s, 60 s, 70/80 s had greater postprandial triglyceride responses versus 20 s.•60 s had the highest frequency of adverse postprandial responses vs. other decades.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging</subject><subject>Blood lipids</subject><subject>Cardiovascular disease</subject><subject>Fasting</subject><subject>Humans</subject><subject>Hypertriglyceridemia - diagnosis</subject><subject>Hypertriglyceridemia - epidemiology</subject><subject>Metabolic health</subject><subject>Older adults</subject><subject>Postprandial Period - physiology</subject><subject>Postprandial triglycerides</subject><subject>Triglycerides</subject><subject>Young Adult</subject><issn>0939-4753</issn><issn>1590-3729</issn><issn>1590-3729</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAURS0Eaqel_wAhL9kkPMdxnLBAqipakCrBAtbWi_0yeJSPwXZGGn49nk5hyeptzn1X9zD2RkApQDTvd-W8TmRdWUElS2hLEPoF2wjVQSF11b1kG-hkV9RayUt2FeMOQGqQ9QW7lFq3bafaDTt8W2LaB5ydx5Gn4Lfj0VLwjiJHG5YYefpJHLd-3vK4J5vCOn3gtzySXWaH4chxxvEYfeRr8qP_fQJx5tj3gQ4eEzk-YOJpGSnXWOKJYnrNXg04Rrp5vtfsx_2n73efi8evD1_ubh8LK4VIRS-bngYnhsrVqhfkBqdw6JAEANROt3XTCYEWG6u0JNFg51RfC6egqqDu5DV7d_67D8uvNRebyUdL44gzLWs0VaurFhpQIqP1GX1aHWgw--CnPNAIMCfjZmfOxs3JuIHWZOM59va5Ye0ncv9CfxVn4OMZoLzz4CmYaD1lEc6HrNO4xf-_4Q-yrJbJ</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Keirns, Bryant H.</creator><creator>Sciarrillo, Christina M.</creator><creator>Poindexter, Kara L.</creator><creator>Dixon, Madison D.</creator><creator>Medlin, Austin R.</creator><creator>Koemel, Nicholas A.</creator><creator>Hart, Samantha M.</creator><creator>Geist, Caroline H.</creator><creator>Jenkins, Nathaniel D.M.</creator><creator>Lucas, Edralin A.</creator><creator>Emerson, Sam R.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2354-1534</orcidid><orcidid>https://orcid.org/0000-0001-5837-4820</orcidid><orcidid>https://orcid.org/0000-0002-5463-6894</orcidid><orcidid>https://orcid.org/0000-0001-7439-0871</orcidid></search><sort><creationdate>202401</creationdate><title>Postprandial triglycerides across the aging spectrum: A secondary analysis utilizing an abbreviated fat tolerance test</title><author>Keirns, Bryant H. ; Sciarrillo, Christina M. ; Poindexter, Kara L. ; Dixon, Madison D. ; Medlin, Austin R. ; Koemel, Nicholas A. ; Hart, Samantha M. ; Geist, Caroline H. ; Jenkins, Nathaniel D.M. ; Lucas, Edralin A. ; Emerson, Sam R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c311t-b36befd1f2d45b1edfd5af9ae10004d7846911aca6c573e16a9d5b41d50220493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging</topic><topic>Blood lipids</topic><topic>Cardiovascular disease</topic><topic>Fasting</topic><topic>Humans</topic><topic>Hypertriglyceridemia - diagnosis</topic><topic>Hypertriglyceridemia - epidemiology</topic><topic>Metabolic health</topic><topic>Older adults</topic><topic>Postprandial Period - physiology</topic><topic>Postprandial triglycerides</topic><topic>Triglycerides</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Keirns, Bryant H.</creatorcontrib><creatorcontrib>Sciarrillo, Christina M.</creatorcontrib><creatorcontrib>Poindexter, Kara L.</creatorcontrib><creatorcontrib>Dixon, Madison D.</creatorcontrib><creatorcontrib>Medlin, Austin R.</creatorcontrib><creatorcontrib>Koemel, Nicholas A.</creatorcontrib><creatorcontrib>Hart, Samantha M.</creatorcontrib><creatorcontrib>Geist, Caroline H.</creatorcontrib><creatorcontrib>Jenkins, Nathaniel D.M.</creatorcontrib><creatorcontrib>Lucas, Edralin A.</creatorcontrib><creatorcontrib>Emerson, Sam R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Keirns, Bryant H.</au><au>Sciarrillo, Christina M.</au><au>Poindexter, Kara L.</au><au>Dixon, Madison D.</au><au>Medlin, Austin R.</au><au>Koemel, Nicholas A.</au><au>Hart, Samantha M.</au><au>Geist, Caroline H.</au><au>Jenkins, Nathaniel D.M.</au><au>Lucas, Edralin A.</au><au>Emerson, Sam R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Postprandial triglycerides across the aging spectrum: A secondary analysis utilizing an abbreviated fat tolerance test</atitle><jtitle>Nutrition, metabolism, and cardiovascular diseases</jtitle><addtitle>Nutr Metab Cardiovasc Dis</addtitle><date>2024-01</date><risdate>2024</risdate><volume>34</volume><issue>1</issue><spage>121</spage><epage>125</epage><pages>121-125</pages><issn>0939-4753</issn><issn>1590-3729</issn><eissn>1590-3729</eissn><abstract>Elevated postprandial triglycerides are an independent cardiovascular disease risk factor and observed in older adults. However, differences in postprandial triglycerides across the spectrum of adulthood remain unclear.
We performed a secondary analysis of six studies where adults (aged 18–84 years; N = 155) completed an abbreviated fat tolerance test (9 kcal/kg; 70% fat). Differences in postprandial triglycerides were compared in those ≥50 and <50 years and by decade of life, adjusting for sex and BMI. Compared to those <50 years, participants ≥50 years had higher fasting, 4 h, and Δ triglycerides from baseline (p's < 0.05). When examining triglyceride parameters by decade, no differences were observed for fasting triglycerides, but 50 s, 60 s, and 70s–80 s displayed greater 4 h and Δ triglycerides versus 20 s (p's ≤ 0.001). The frequency of adverse postprandial triglyceride responses (i.e., ≥220 mg/dL) was higher in participants ≥50 versus <50 years (p < 0.01), and in 60 s compared to all other decades (p = 0.01).
Older age was generally associated with higher postprandial triglycerides, with no divergence across the spectrum of older adulthood. In our sample, postprandial triglyceride differences in older and younger adults were driven by those >50 years relative to young adults in their 20 s.
N/A (secondary analysis).
•Fasting triglycerides were similar across all decades of life.•Yet, 50 s, 60 s, 70/80 s had greater postprandial triglyceride responses versus 20 s.•60 s had the highest frequency of adverse postprandial responses vs. other decades.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>37788958</pmid><doi>10.1016/j.numecd.2023.08.017</doi><tpages>5</tpages><orcidid>https://orcid.org/0000-0002-2354-1534</orcidid><orcidid>https://orcid.org/0000-0001-5837-4820</orcidid><orcidid>https://orcid.org/0000-0002-5463-6894</orcidid><orcidid>https://orcid.org/0000-0001-7439-0871</orcidid></addata></record> |
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| ispartof | Nutrition, metabolism, and cardiovascular diseases, 2024-01, Vol.34 (1), p.121-125 |
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| language | eng |
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| source | ScienceDirect Freedom Collection |
| subjects | Adult Aged Aging Blood lipids Cardiovascular disease Fasting Humans Hypertriglyceridemia - diagnosis Hypertriglyceridemia - epidemiology Metabolic health Older adults Postprandial Period - physiology Postprandial triglycerides Triglycerides Young Adult |
| title | Postprandial triglycerides across the aging spectrum: A secondary analysis utilizing an abbreviated fat tolerance test |
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