Evaluating the efficiency and safety of large‐volume leukapheresis using the Spectra Optia continuous mononuclear cell collection protocol for peripheral blood stem cell collection from healthy donors: A retrospective study

Background Large‐volume leukapheresis (LVL) refers to processing of more than three volumes of blood in a single session for peripheral blood stem cell collection. Recently, continuous mononuclear cell collection (cMNC) protocol has been developed using the Spectra Optia system, which is a widely us...

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Published in:Transfusion (Philadelphia, Pa.) Pa.), 2023-11, Vol.63 (11), p.2120-2130
Main Authors: Sumii, Yuichi, Fujii, Keiko, Kondo, Takumi, Urata, Tomohiro, Kimura, Maiko, Fujiwara, Hideaki, Asada, Noboru, Ennishi, Daisuke, Nishimori, Hisakazu, Matsuoka, Ken‐ichi, Otsuka, Fumio, Maeda, Yoshinobu, Fujii, Nobuharu
Format: Article
Language:English
Subjects:
Apheresis
Blood
blood center operations
Blood volume
CD34 antigen
Data collection
Efficiency
Hematopoietic stem cells
Leukapheresis
Peripheral blood
Platelets
Safety
Spectra
Stem cell transplantation
Stem cells
therapeutic apheresis
Toxicity
transplantation—stem cell
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Summary:Background Large‐volume leukapheresis (LVL) refers to processing of more than three volumes of blood in a single session for peripheral blood stem cell collection. Recently, continuous mononuclear cell collection (cMNC) protocol has been developed using the Spectra Optia system, which is a widely used apheresis device. LVL using the novel protocol has been investigated in patients. However, the efficiency and safety of LVL in healthy donors using this protocol has not been characterized. Therefore, this study aimed to evaluate the efficiency and tolerability of CD34+ collection of LVL with the cMNC protocol in healthy donors. Study Design and Methods We retrospectively collected data on LVL (>3 total blood volume) and normal‐volume leukapheresis (NVL) performed in healthy donors between October 2019 and December 2021. All procedures were performed using the cMNC protocol. Results Although pre‐apheresis CD34+ cell count was lesser in LVL (23.5 vs. 58.0/μL, p 
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.17563