Dispersion and diversification of Lyssavirus rabies transmitted from haematophagous bats Desmodus rotundus: a phylogeographical study

Rabies is worldwide zoonosis caused by Lyssavirus rabies (RABV) a RNA negative sense virus with low level of fidelity during replication cycle. Nucleoprotein of RABV is the most conserved between all five proteins of the virus and is the most used gene for phylogenetic and phylogeographic studies. D...

Full description

Saved in:
Bibliographic Details
Published in:Virus genes 2023-12, Vol.59 (6), p.817-822
Main Authors: de Carvalho Ruthner Batista, Helena Beatriz, Vieira, Luiz Fernando Pereira, Kawai, Juliana Galera Castilho, de Oliveira Fahl, Willian, Barboza, Camila Mosca, Achkar, Samira, de Novaes Oliveira, Rafael, Brandão, Paulo Eduardo, Carnieli Junior, Pedro
Format: Article
Language:English
Subjects:
Bayesian analysis
Biomedical and Life Sciences
Biomedicine
Cattle
Central nervous system
Desmodus rotundus
Lyssavirus
Medical Microbiology
Original Paper
Phylogeny
Phylogeography
Plant Sciences
Public health
Rabies
RNA viruses
Virology
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Rabies is worldwide zoonosis caused by Lyssavirus rabies (RABV) a RNA negative sense virus with low level of fidelity during replication cycle. Nucleoprotein of RABV is the most conserved between all five proteins of the virus and is the most used gene for phylogenetic and phylogeographic studies. Despite of rabies been very important in Public Health concern, it demands continuous prophylactic care for herbivores with economic interest, such as cattle and horses. The main transmitter of RABV for these animals in Brazil is the hematophagous bats Desmodus rotundus . The aim of this study was to determine the dispersion over time and space of RABV transmitted by D. rotundus . Samples of RABV from the State of São Paulo (SP), Southeast Brazil isolated from the central nervous system (CNS) of cattle, were submitted to RNA extraction, RT-PCR, sequencing and phylogeographic analyzes with BEAST (Bayesian Evolutionary Analysis Sampling Trees) v 2.5 software. Was possible to identify high rate of diversification in starts sublineages of RABV what are correlated with a behavior of D. rotundus , the main transmitter of rabies to cattle. This study also highlights the importance of continuous monitoring of genetic lineages of RABV in Brazil.
ISSN:0920-8569
1572-994X
DOI:10.1007/s11262-023-02030-x