Nanotechnology‐Based Strategies for Extended‐Release Delivery of Angiotensin Receptor Blockers (ARBs): A Comprehensive Review

There has been a significant shift in the perception of hypertension as an important contributor to the global disease burden. Approximately 6 % and 8 % of pregnancies are affected by hypertension, which can adversely affect the mother and the fetus. Furthermore, a hypertensive individual is at incr...

Full description

Saved in:
Bibliographic Details
Published in:Chemistry & biodiversity 2023-11, Vol.20 (11), p.e202301157-n/a
Main Authors: Haji Ali, Bahareh, Shirvaliloo, Milad, Fathi‐Karkan, Sonia, Mirinejad, Shekoufeh, Ulucan‐Karnak, Fulden, Sargazi, Saman, Sargazi, Sara, Sheervalilou, Roghayeh, Rahman, Mohammed M.
Format: Article
Language:English
Subjects:
Angiotensin
angiotensin receptor blockers (ARBs)
Bioavailability
Cardiovascular disease
Congestive heart failure
Coronary artery disease
Dendrimers
Diabetes
Diabetes mellitus
Drug delivery
Drug delivery systems
Fetuses
Heart diseases
Hypertension
Kidney diseases
Lipids
Micelles
Nanocrystals
Nanoemulsions
Nanoparticles
Nanotechnology
Nephropathy
Polymers
receptor blockers
Receptors
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There has been a significant shift in the perception of hypertension as an important contributor to the global disease burden. Approximately 6 % and 8 % of pregnancies are affected by hypertension, which can adversely affect the mother and the fetus. Furthermore, a hypertensive individual is at increased risk of developing kidney disease, arterial hardening, eye damage, and strokes. Using angiotensin receptor blockers (ARBs) is widespread in treating hypertension, heart failure, coronary artery disease, and diabetic nephropathy. Despite this, some ARBs have limited use due to their poor oral bioavailability and water solubility. To tackle this, a variety of nanoparticle (NP)‐based systems, such as polymeric NPs (i. e., dendrimers), polymeric micelles, polymer‐drug conjugates, lipid NPs, nanoemulsions, self‐emulsifying drug delivery systems (SEDDS), solid lipid NPs (SLNs), nanostructured lipid carriers (NLCs), carbon‐based nanocarriers, inorganic NPs, and nanocrystals, have been recently developed for efficient delivery of losartan, Valsartan (Val), Olmesartan (OLM), Telmisartan (TEL), Candesartan, Eprosartan, Irbesartan, and Azilsartan to target cells. This review article provides a literature‐based comparison of the various classes of ARBs, their mechanisms of action, and an overview of the nanoformulations developed for ARB delivery and successfully applied to managing hypertension, diabetic complications, and other conditions.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.202301157