Recognition and perception of emotions in juvenile myoclonic epilepsy

• Published in: Epilepsia (Copenhagen) 2023-12, Vol.64 (12), p.3319-3330
• Main Authors: Rainer, Lucas Johannes, Kuchukhidze, Giorgi, Trinka, Eugen, Braun, Mario, Kronbichler, Martin, Langthaler, Patrick, Zimmermann, Georg, Kronbichler, Lisa, Said‐Yürekli, Sarah, Kirschner, Margarita, Zamarian, Laura, Schmid, Elisabeth, Jokeit, Hennric, Höfler, Julia
• Format: Article
• Language: English
• Subjects: affective; Amygdala; Cognitive ability; Comorbidity; emotion perception; emotion recognition; Emotional behavior; Emotions; Epilepsy; Executive function; Functional magnetic resonance imaging; JME; Magnetic resonance imaging; Measuring techniques; Mental disorders; NEmo; Neuropsychology; Patients; Pattern recognition; Perception; Psychology; Seizures
• ISSN: 0013-9580; 1528-1167
• DOI: 10.1111/epi.17783

Objective Perception and recognition of emotions are fundamental prerequisites of human life. Patients with juvenile myoclonic epilepsy (JME) may have emotional and behavioral impairments that might influence socially desirable interactions. We aimed to investigate perception and recognition of emotions in patients with JME by means of neuropsychological tests and functional magnetic resonance imaging (fMRI). Methods Sixty‐five patients with JME (median age = 27 years, interquartile range [IQR] = 23–34) were prospectively recruited at the Department of Neurology, Christian Doppler University Hospital, Paracelsus Medical University, Salzburg, Austria. Patients were compared to 68 healthy controls (median age = 24 years, IQR = 21–31), matched for sex, age, and education. All study participants underwent the Networks of Emotion Processing test battery (NEmo), an fMRI paradigm of “dynamic fearful faces,” a structured interview for psychiatric and personality disorders, and comprehensive neuropsychological testing. Results JME patients versus healthy controls demonstrated significant deficits in emotion recognition in facial and verbal tasks of all emotions, especially fear. fMRI revealed decreased amygdala activation in JME patients as compared to healthy controls. Patients were at a higher risk of experiencing psychiatric disorders as compared to healthy controls. Cognitive evaluation revealed impaired attentional and executive functioning, namely psychomotor speed, tonic alertness, divided attention, mental flexibility, and inhibition of automated reactions. Duration of epilepsy correlated negatively with parallel prosodic and facial emotion recognition in NEmo. Deficits in emotion recognition were not associated with psychiatric comorbidities, impaired attention and executive functions, types of seizures, and treatment. Significance This prospective study demonstrated that as compared to healthy subjects, patients with JME had significant deficits in recognition and perception of emotions as shown by neuropsychological tests and fMRI. The results of this study may have importance for psychological/psychotherapeutic interventions in the management of patients with JME.