Structural characteristics and structure-activity relationship of four polysaccharides from Lycii fructus

At present, the structure-activity relationship of polysaccharides is a common and important focus in the fields of glycobiology and carbohydrate chemistry. To better understand the effect of specific polysaccharide structures on bioactive orientation, four homogeneous polysaccharides from Lycii fru...

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Bibliographic Details
Published in:International journal of biological macromolecules 2023-12, Vol.253, p.127256-127256, Article 127256
Main Authors: Liang, Xiaofei, Liu, Mengqiu, Wei, Yan, Tong, Limei, Guo, Sheng, Kang, Hongjie, Zhang, Wenhua, Yu, Zhexiong, Zhang, Fang, Duan, Jin-ao
Format: Article
Language:English
Subjects:
Lycii fructus
Polysaccharides
Structural characteristics
Structure-activity relationship
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Summary:At present, the structure-activity relationship of polysaccharides is a common and important focus in the fields of glycobiology and carbohydrate chemistry. To better understand the effect of specific polysaccharide structures on bioactive orientation, four homogeneous polysaccharides from Lycii fructus, one neutral along with three acidic polysaccharides, were purified, structurally characterized and comparatively evaluated on the antioxidative and anti-aging activities. The GC–MS-based monosaccharide composition analysis and methylation results showed that the LFPs had similar glycosyl types but varied proportions. Nuclear magnetic resonance (NMR) spectroscopy showed that LFPs consisted of arabinogalactan, rhamnogalacturonan and homogalacturonan structural domains. The results of the structure-activity relationship indicated that the antioxidative activity was positively correlated with the galacturonic acid (GalA) content, while the neutral multi-branched chains might be responsible for the anti-aging activity. This study is the first time to compare the principal structures and multiple biological activities of LFPs, which provided a reference for the industrial development and deep excavation of the health value of LFPs. [Display omitted] •The structure of one neutral and three acidic polysaccharides from Lycii fructus was elucidated by physicochemical composition and intrinsic accumulation patterns•Neutral multi-branched polysaccharides have a stronger age-related gene regulation than acid polysaccharides•Acidic polysaccharides with proper Mw and GalA content exhibited stronger antioxidant capacity in vitro•The structure and activity of polysaccharides were closely related
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.127256