A single-cell atlas of the rat amygdala reveals molecular signatures of cocaine addiction

We used single-nucleus sequencing to generate an atlas of gene expression and chromatin accessibility in the amygdala of outbred rats with divergent cocaine addiction-like behaviors. The results implicated dysregulation of metabolic pathways and GABAergic transmission as molecular bases of susceptib...

Full description

Saved in:
Bibliographic Details
Published in:Nature neuroscience 2023-11, Vol.26 (11), p.1838-1839
Format: Article
Language:English
Subjects:
631/337/2019
631/378/1689
Abstinence
Addictions
Addictive behaviors
Amygdala
Animal Genetics and Genomics
Behavior
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Chromatin
Cocaine
Drug abuse
Enzymes
Gene expression
Genetic engineering
Genomics
Metabolic pathways
Metabolism
Narcotics
Neurobiology
Neurosciences
Pandemics
Research Briefing
γ-Aminobutyric acid
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We used single-nucleus sequencing to generate an atlas of gene expression and chromatin accessibility in the amygdala of outbred rats with divergent cocaine addiction-like behaviors. The results implicated dysregulation of metabolic pathways and GABAergic transmission as molecular bases of susceptibility or resistance to addiction.
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-023-01454-w