Co-production of 2,5-dihydroxymethylfuran and furfuralcohol from sugarcane bagasse via chemobiocatalytic approach in a sustainable system

[Display omitted] •Bagasse was catalyzed to yield HMF (48 mM) and FAL (14 mM) by CTA:BT (170 °C, 0.5 h).•Reduction of HMF and FAL was conducted by SCFD23 cell co-expressing FDH and SsCR.•Bagasse was transformed into furans via a chemobiocatalytical approach in DES-water.•Co-production of DHMF and FO...

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Bibliographic Details
Published in:Bioresource technology 2023-12, Vol.389, p.129819-129819, Article 129819
Main Authors: Li, Yucheng, Pan, Lei, He, Yu-Cai
Format: Article
Language:English
Subjects:
2,5-Dihydroxymethylfuran
5-Hydroxymethylfurfural
Bagasse
Furfural
Furfuryl alcohol
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Summary:[Display omitted] •Bagasse was catalyzed to yield HMF (48 mM) and FAL (14 mM) by CTA:BT (170 °C, 0.5 h).•Reduction of HMF and FAL was conducted by SCFD23 cell co-expressing FDH and SsCR.•Bagasse was transformed into furans via a chemobiocatalytical approach in DES-water.•Co-production of DHMF and FOL was conducted from biomass in one-pot two-step way. 2,5-Dihydroxymethylfuran and furfuryl alcohol serve as versatile building-blocks in pharmaceuticals, polymers, and value-added intermediates. To develop an efficient and sustainable method for their production from biomass, a combined approach using deep eutectic solvent Citric acid:Betaine (CTA:BT) for bagasse catalysis and recombinant E. coli SCFD23 for bioreduction of bagasse-derived 5-hydroxymethylfurfural and furfural was devised. Bagasse was effectively transformed into 5-hydroxymethylfurfural (47.9 mM) and furfural (14.0 mM) in CTA:BT (8 wt%)-water at 170 °C for 30 min. Bioreduction of 5-hydroxymethylfurfural and furfural by SCFD23 cell co-expressing formate dehydrogenase and NAD(P)H-dependent aldehyde reductase (SsCR) yielded 2,5-dihydroxymethylfuran (90.0 % yield) and furfuryl alcohol (99.0 % yield) in 6 h, using biomass-derived formic acid, xylose and glucose as co-substrates. Molecular docking confirmed the stable binding and reductase activity of SsCR with the biomass-derived 5-hydroxymethylfurfural and furfural. An efficient and eco-friendly chemobiological approach was applied for co-production of 2,5-dihydroxymethylfuran and furfuryl alcohol from biomass in one-pot two-step reaction.
ISSN:0960-8524
1873-2976
DOI:10.1016/j.biortech.2023.129819