Organophosphorus and carbamate pesticides: Molecular toxicology and laboratory testing

[Display omitted] •OP/OC poisoning is rampant.•AChE activity is the gold standard biomarker.•AChE activity cannot distinguish between OP and OC toxicity.•OP and OC have other targets and are crucial.•Biomarker of distinction is necessary. Population and food requirements are increasing daily through...

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Published in:Clinica chimica acta 2023-11, Vol.551, p.117584-117584, Article 117584
Main Authors: Kaur, Sumanpreet, Chowdhary, Sheemona, Kumar, Deepak, Bhattacharyya, Rajasri, Banerjee, Dibyajyoti
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Carbamates - toxicity
Detection
Humans
Pesticides
Pesticides - toxicity
Specific Biomarker
Suicide
Toxicity
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Summary:[Display omitted] •OP/OC poisoning is rampant.•AChE activity is the gold standard biomarker.•AChE activity cannot distinguish between OP and OC toxicity.•OP and OC have other targets and are crucial.•Biomarker of distinction is necessary. Population and food requirements are increasing daily throughout the world. To fulfil these requirements application of pesticides is also increasing. Organophosphorous (OP) and Organocarbamate (OC) compounds are widely used pesticides. These pesticides are used for suicidal purposes too. Both inhibit Acetylcholinesterase (AChE) and cholinergic symptoms are mainly used for the diagnosis of pesticide poisoning. Although the symptoms of the intoxication of OP and OC are similar, recent research has described different targets for OP and OC pesticides. Researchers believe the distinction of OP/OC poisoning will be beneficial for the management of pesticide exposure. OP compounds produce adducts with several proteins. There is a new generation of OP compounds like glyphosate that do not inhibit AChE. Therefore, it’s high time to develop biomarkers that can distinguish OP poisoning from OC poisoning.
ISSN:0009-8981
1873-3492
DOI:10.1016/j.cca.2023.117584