Electrospun polyvinyl alcohol/ Withania somnifera extract nanofibers incorporating tadalafil-loaded nanoparticles for diabetic ulcers

Impaired inflammation and vascularization are common reasons for delayed diabetic wound healing. Nanoparticles (NPs)-in-nanofibers composites can manage diabetic wounds. A multifunctional scaffold was developed based on tadalafil (TDF)-loaded NPs incorporated into polyvinyl alcohol/ extract nanofibe...

Full description

Saved in:
Bibliographic Details
Published in:Nanomedicine (London, England) England), 2023-08, Vol.18 (20), p.1361-1382
Main Authors: Elsherbini, Asmaa M, Sabra, Sally A, Rashed, Shimaa A, Abdelmonsif, Doaa A, Haroun, Medhat, Shalaby, Thanaa I
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - chemistry
Diabetes Mellitus - drug therapy
Inflammation - drug therapy
Nanofibers - chemistry
Nanoparticles - chemistry
Polyvinyl Alcohol - chemistry
Rats
Tadalafil
Ulcer - drug therapy
Withania
Wound Healing
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Impaired inflammation and vascularization are common reasons for delayed diabetic wound healing. Nanoparticles (NPs)-in-nanofibers composites can manage diabetic wounds. A multifunctional scaffold was developed based on tadalafil (TDF)-loaded NPs incorporated into polyvinyl alcohol/ extract nanofibers. TDF-loaded NPs were prepared and fully characterized in terms of their physicochemical properties. Extract of ashwagandha was prepared and a blend composed of TDF-loaded NPs, herbal extract and polyvinyl alcohol was used to prepare the whole composite. The whole composite exhibited improved wound closure in a diabetic rat model in terms of reduced inflammation and enhanced angiogenesis. Results suggest that this multifunctional composite could serve as a promising diabetic wound dressing.
ISSN:1743-5889
1748-6963
DOI:10.2217/nnm-2023-0127