Classification of Escherichia coli K-12 ribosome binding sites

Drawing on parallels between genetic information processing in living organisms and the processing of communications data, we develop an error-control coding-based translation initiation classification system that uses an eleven base classification window. An overview of channel codes and a summary...

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Bibliographic Details
Published in:IEEE engineering in medicine and biology magazine 2006-01, Vol.25 (1), p.90-97
Main Authors: May, E.E., Vouk, M.A., Bitzer, D.L.
Format: Article
Language:English
Subjects:
Bayesian analysis
Bayesian methods
Bioinformatics
Biological information theory
Biological system modeling
Escherichia coli
Genetic communication
Genomics
Hidden Markov models
Information theory
Proteins
Sequences
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Summary:Drawing on parallels between genetic information processing in living organisms and the processing of communications data, we develop an error-control coding-based translation initiation classification system that uses an eleven base classification window. An overview of channel codes and a summary of the translation initiation process are presented. Parallels between the two are drawn and a brief review of a channel code model for translation initiation is shown. A block-code Bayesian classifier is presented and the results of applying the system to the translation start site location problem for Escherichia coli K-12 is discussed.
ISSN:0739-5175
1937-4186
DOI:10.1109/MEMB.2006.1578668