The protective role of 5-hydroxy-1,4-naphthoquinone against the harmful effects of 50 Hz electric field in rat lung tissue

There is strong scientific evidence that the electric field is harmful to life. Exposure to an electric field (EF) can cause lung toxicity and respiratory disorders. In addition, the electric field has been shown to cause tissue damage through inflammation and apoptosis. Juglone (JUG) is one of the...

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Published in:Electromagnetic biology and medicine 2023-10, Vol.42 (4), p.133-143
Main Authors: Şenol, Nurgül, Şahin, Melda, Şahin, Uğur
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
Antioxidants - pharmacology
Electricity
Lung
Naphthoquinones - pharmacology
Rats
Rats, Wistar
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container_title Electromagnetic biology and medicine
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creator Şenol, Nurgül
Şahin, Melda
Şahin, Uğur
description There is strong scientific evidence that the electric field is harmful to life. Exposure to an electric field (EF) can cause lung toxicity and respiratory disorders. In addition, the electric field has been shown to cause tissue damage through inflammation and apoptosis. Juglone (JUG) is one of the powerful antioxidants with anti-apoptotic and anti-inflammatory, various pharmacological properties in the biological system. In this study, we evaluated the efficacy of JUG against the potential adverse effects of electric field on the lung. Twenty-four Wistar albino rats were randomly divided into three groups; control group (Cont), EF group, and EF exposure+JUG-treated group (EJUG). After routine histological procedures, sections stained with hematoxylin-eosin (H&E) showed significant changes in lung tissues in the EF group compared to the Cont group. Significant protective effects were observed in the building volumes and histopathology in the EJUG group. Our immunohistochemical and gene expression results increased the expression of caspase-3 and tumor necrosis factor alpha (TNF-α) in the EF group (  
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Our immunohistochemical and gene expression results increased the expression of caspase-3 and tumor necrosis factor alpha (TNF-α) in the EF group (  &lt; 0.05). Juglon increased cytokine signal suppressor (SOCS) expression (  &lt; 0.001). These findings were consistent with the antioxidant effect of JUG treatment. 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subjects Animals
Antioxidants - metabolism
Antioxidants - pharmacology
Electricity
Lung
Naphthoquinones - pharmacology
Rats
Rats, Wistar
title The protective role of 5-hydroxy-1,4-naphthoquinone against the harmful effects of 50 Hz electric field in rat lung tissue
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