Wavelet analysis of oscillations in the peripheral blood circulation measured by laser Doppler technique

The wavelet transform technique, a time-frequency method with logarithmic frequency resolution, was used to analyze oscillations in human peripheral blood flow measured by laser Doppler flowmetry. The oscillations extended over a wide frequency state and their periods varied in time. Within the freq...

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Bibliographic Details
Published in:IEEE transactions on biomedical engineering 1999-10, Vol.46 (10), p.1230-1239
Main Authors: Stefanovska, A., Bracic, M., Kvernmo, H.D.
Format: Article
Language:English
Subjects:
Acetylcholine - pharmacology
Biological and medical sciences
Biomedical measurements
Blood flow
Capillary flow
Cardiovascular system
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiology
Flow measurement
Fluid flow measurement
Frequency measurement
Humans
Investigative techniques, diagnostic techniques (general aspects)
Iontophoresis
Laser Doppler velocimeters
Laser-Doppler Flowmetry - methods
Light scattering
Male
Measurement by laser beam
Medical sciences
Nitroprusside - pharmacology
Numerical analysis
Oscillations
Oscillometry - methods
Physiology
Pulsatile Flow - drug effects
Red blood cells
Regional Blood Flow - drug effects
Signal Processing, Computer-Assisted
Skin - blood supply
Ultrasonic investigative techniques
Vasodilation - drug effects
Vasodilator Agents - pharmacology
Velocity measurement
Wavelet analysis
Wavelet transforms
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Description
Summary:The wavelet transform technique, a time-frequency method with logarithmic frequency resolution, was used to analyze oscillations in human peripheral blood flow measured by laser Doppler flowmetry. The oscillations extended over a wide frequency state and their periods varied in time. Within the frequency range studied, 0.0095-1.6 Hz, five characteristic oscillations were revealed, arising from both local and central regulatory mechanisms. After the insertion of endothelium-dependent and endothelium-independent vasodilators the spectra of blood how markedly differed in the frequency interval 0.0095-0.02 Hz. In this way it was demonstrated that endothelial activity is a rhythmic process that contributes to oscillations in blood flow with a characteristic frequency of around 0.01 Hz. The study illustrates the potential of laser Doppler flowmetry combined with dynamical systems analysis for studies of both the micro- and macroscopic mechanisms of blood flow regulation in vivo.
ISSN:0018-9294
1558-2531
DOI:10.1109/10.790500