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Impaired gastric accommodation in patients with postprandial distress syndrome type of functional dyspepsia assessed by 2D ultrasonography
Background and Purpose The pathophysiology of postprandial distress syndrome includes impaired gastric accommodation, hypersensitivity to gastric distension and delayed gastric emptying. 2D-ultrasonography is one of the methods to assess gastric accommodation by measuring proximal gastric area and w...
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| Published in: | Indian journal of gastroenterology 2023-12, Vol.42 (6), p.824-832 |
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| cites | cdi_FETCH-LOGICAL-c347t-b5ad200620ba75b45f5542688e5a0128b677eb9eacbdab3affc81f1b959708ec3 |
| container_end_page | 832 |
| container_issue | 6 |
| container_start_page | 824 |
| container_title | Indian journal of gastroenterology |
| container_volume | 42 |
| creator | Ahmed, Ishtkhar Udawat, Harsh Prasad Ansari, Mohsin Yadav, Rajeev Vaishnav, Sandeep Agrawal, Dinesh Govil, Anurag Purohit, Sunita |
| description | Background and Purpose
The pathophysiology of postprandial distress syndrome includes impaired gastric accommodation, hypersensitivity to gastric distension and delayed gastric emptying. 2D-ultrasonography is one of the methods to assess gastric accommodation by measuring proximal gastric area and we evaluated its role in calculating proximal gastric area and thus assessing gastric accommodation in Indian patients with postprandial distress syndrome.
Methods
In a hospital-based comparative analysis, proximal gastric area was measured with 2D-ultrasonography of postprandial distress syndrome (PDS) patients and compared with healthy controls. Five readings were measured every five minutes till 25 minutes after 400 mL of vegetable soup. The Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life (PAGI-QOL score) and diets aggravating PDS symptoms were studied through detailed questionnaires. Sample size was calculated at 80% study power and alpha error of 0.05 to be 30 subjects in each group.
Results
The mean age of patients (18 males) vs. 30 healthy controls (25 males) was 40.8 ± 11.50 years vs. 36.37 ± 7.58, respectively, (
p
= 0.084). Proximal gastric area was significantly lower in patients versus healthy controls at five minutes (22.54 ± 2.77 vs. 30.66 ± 2.55 cm
2
), 10 minutes (23.03 ± 2.45 vs. 31.10 ± 2.06 cm
2
), 15 minutes (23.06 ± 2.27 vs. 30.31 ± 2.11 cm
2
), 20 minutes (22.21 ± 2.31 vs. 29.73 ± 1.71 cm
2
) and 25 minutes (22.02 ± 2.33 vs. 28.39 ± 1.55 cm
2
);
p
|
| doi_str_mv | 10.1007/s12664-023-01436-7 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2875381429</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2875381429</sourcerecordid><originalsourceid>FETCH-LOGICAL-c347t-b5ad200620ba75b45f5542688e5a0128b677eb9eacbdab3affc81f1b959708ec3</originalsourceid><addsrcrecordid>eNp9kcFu1TAQRS1ERUvhB1ggL9kEbCeOnSUqBSpVYlPW1thxXl0ltvEkQvmFfnX9eIUlq5mRz72W7iXkHWcfOWPqE3LR913DRNsw3rV9o16QCzYo2TDF-cu6C9k1WvfsnLxGfGDHe2hfkfNWad5x3l-Qx5slQyh-pAfAtQRHwbm0LGmENaRIQ6S5bj6uSH-H9Z7mhGsuEMcAMx1D1XhEinscS1o8XffsaZrotEV3NDhCO2afMQAFxArXv-xOxRe6zWsBTDEdCuT7_Q05m2BG__Z5XpKfX6_vrr43tz--3Vx9vm1c26m1sRJGwVgvmAUlbScnKTvRa-0lMC607ZXydvDg7Ai2hWlymk_cDnJQTHvXXpIPJ99c0q_N42qWgM7PM0SfNjRCK9nWfMRQUXFCXUmIxU8ml7BA2Q1n5tiBOXVgagfmTwdGVdH7Z__NLn78J_kbegXaE4D1KR58MQ9pKzUq_J_tE5p7lmU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2875381429</pqid></control><display><type>article</type><title>Impaired gastric accommodation in patients with postprandial distress syndrome type of functional dyspepsia assessed by 2D ultrasonography</title><source>Springer Nature</source><creator>Ahmed, Ishtkhar ; Udawat, Harsh Prasad ; Ansari, Mohsin ; Yadav, Rajeev ; Vaishnav, Sandeep ; Agrawal, Dinesh ; Govil, Anurag ; Purohit, Sunita</creator><creatorcontrib>Ahmed, Ishtkhar ; Udawat, Harsh Prasad ; Ansari, Mohsin ; Yadav, Rajeev ; Vaishnav, Sandeep ; Agrawal, Dinesh ; Govil, Anurag ; Purohit, Sunita</creatorcontrib><description>Background and Purpose
The pathophysiology of postprandial distress syndrome includes impaired gastric accommodation, hypersensitivity to gastric distension and delayed gastric emptying. 2D-ultrasonography is one of the methods to assess gastric accommodation by measuring proximal gastric area and we evaluated its role in calculating proximal gastric area and thus assessing gastric accommodation in Indian patients with postprandial distress syndrome.
Methods
In a hospital-based comparative analysis, proximal gastric area was measured with 2D-ultrasonography of postprandial distress syndrome (PDS) patients and compared with healthy controls. Five readings were measured every five minutes till 25 minutes after 400 mL of vegetable soup. The Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life (PAGI-QOL score) and diets aggravating PDS symptoms were studied through detailed questionnaires. Sample size was calculated at 80% study power and alpha error of 0.05 to be 30 subjects in each group.
Results
The mean age of patients (18 males) vs. 30 healthy controls (25 males) was 40.8 ± 11.50 years vs. 36.37 ± 7.58, respectively, (
p
= 0.084). Proximal gastric area was significantly lower in patients versus healthy controls at five minutes (22.54 ± 2.77 vs. 30.66 ± 2.55 cm
2
), 10 minutes (23.03 ± 2.45 vs. 31.10 ± 2.06 cm
2
), 15 minutes (23.06 ± 2.27 vs. 30.31 ± 2.11 cm
2
), 20 minutes (22.21 ± 2.31 vs. 29.73 ± 1.71 cm
2
) and 25 minutes (22.02 ± 2.33 vs. 28.39 ± 1.55 cm
2
);
p
< 0.001 at all intervals of time, indicating impaired gastric accommodation. The QOL was poor in all patients with PDS with mean PAGI-QOL score of 31.30 ± 15.05, median of 30, minimum score of 12 and maximum score of 66.
Conclusions
Measurement of proximal gastric area with 2D-ultrasonography is simple and non-invasive. Proximal gastric area in patients was lower than controls, indicating impaired gastric accommodation. Poor quality of life was universal in patients with postprandial distress syndrome.
Graphical Abstract</description><identifier>ISSN: 0254-8860</identifier><identifier>EISSN: 0975-0711</identifier><identifier>DOI: 10.1007/s12664-023-01436-7</identifier><identifier>PMID: 37814116</identifier><language>eng</language><publisher>New Delhi: Springer India</publisher><subject>Dyspepsia - diagnostic imaging ; Gastric Emptying ; Gastroenterology ; Hepatology ; Humans ; Male ; Medicine ; Medicine & Public Health ; Original Article ; Postprandial Period - physiology ; Quality of Life ; Stomach - diagnostic imaging ; Stomach Diseases ; Ultrasonography</subject><ispartof>Indian journal of gastroenterology, 2023-12, Vol.42 (6), p.824-832</ispartof><rights>Indian Society of Gastroenterology 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. Indian Society of Gastroenterology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c347t-b5ad200620ba75b45f5542688e5a0128b677eb9eacbdab3affc81f1b959708ec3</citedby><cites>FETCH-LOGICAL-c347t-b5ad200620ba75b45f5542688e5a0128b677eb9eacbdab3affc81f1b959708ec3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27907,27908</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37814116$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ahmed, Ishtkhar</creatorcontrib><creatorcontrib>Udawat, Harsh Prasad</creatorcontrib><creatorcontrib>Ansari, Mohsin</creatorcontrib><creatorcontrib>Yadav, Rajeev</creatorcontrib><creatorcontrib>Vaishnav, Sandeep</creatorcontrib><creatorcontrib>Agrawal, Dinesh</creatorcontrib><creatorcontrib>Govil, Anurag</creatorcontrib><creatorcontrib>Purohit, Sunita</creatorcontrib><title>Impaired gastric accommodation in patients with postprandial distress syndrome type of functional dyspepsia assessed by 2D ultrasonography</title><title>Indian journal of gastroenterology</title><addtitle>Indian J Gastroenterol</addtitle><addtitle>Indian J Gastroenterol</addtitle><description>Background and Purpose
The pathophysiology of postprandial distress syndrome includes impaired gastric accommodation, hypersensitivity to gastric distension and delayed gastric emptying. 2D-ultrasonography is one of the methods to assess gastric accommodation by measuring proximal gastric area and we evaluated its role in calculating proximal gastric area and thus assessing gastric accommodation in Indian patients with postprandial distress syndrome.
Methods
In a hospital-based comparative analysis, proximal gastric area was measured with 2D-ultrasonography of postprandial distress syndrome (PDS) patients and compared with healthy controls. Five readings were measured every five minutes till 25 minutes after 400 mL of vegetable soup. The Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life (PAGI-QOL score) and diets aggravating PDS symptoms were studied through detailed questionnaires. Sample size was calculated at 80% study power and alpha error of 0.05 to be 30 subjects in each group.
Results
The mean age of patients (18 males) vs. 30 healthy controls (25 males) was 40.8 ± 11.50 years vs. 36.37 ± 7.58, respectively, (
p
= 0.084). Proximal gastric area was significantly lower in patients versus healthy controls at five minutes (22.54 ± 2.77 vs. 30.66 ± 2.55 cm
2
), 10 minutes (23.03 ± 2.45 vs. 31.10 ± 2.06 cm
2
), 15 minutes (23.06 ± 2.27 vs. 30.31 ± 2.11 cm
2
), 20 minutes (22.21 ± 2.31 vs. 29.73 ± 1.71 cm
2
) and 25 minutes (22.02 ± 2.33 vs. 28.39 ± 1.55 cm
2
);
p
< 0.001 at all intervals of time, indicating impaired gastric accommodation. The QOL was poor in all patients with PDS with mean PAGI-QOL score of 31.30 ± 15.05, median of 30, minimum score of 12 and maximum score of 66.
Conclusions
Measurement of proximal gastric area with 2D-ultrasonography is simple and non-invasive. Proximal gastric area in patients was lower than controls, indicating impaired gastric accommodation. Poor quality of life was universal in patients with postprandial distress syndrome.
Graphical Abstract</description><subject>Dyspepsia - diagnostic imaging</subject><subject>Gastric Emptying</subject><subject>Gastroenterology</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Original Article</subject><subject>Postprandial Period - physiology</subject><subject>Quality of Life</subject><subject>Stomach - diagnostic imaging</subject><subject>Stomach Diseases</subject><subject>Ultrasonography</subject><issn>0254-8860</issn><issn>0975-0711</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kcFu1TAQRS1ERUvhB1ggL9kEbCeOnSUqBSpVYlPW1thxXl0ltvEkQvmFfnX9eIUlq5mRz72W7iXkHWcfOWPqE3LR913DRNsw3rV9o16QCzYo2TDF-cu6C9k1WvfsnLxGfGDHe2hfkfNWad5x3l-Qx5slQyh-pAfAtQRHwbm0LGmENaRIQ6S5bj6uSH-H9Z7mhGsuEMcAMx1D1XhEinscS1o8XffsaZrotEV3NDhCO2afMQAFxArXv-xOxRe6zWsBTDEdCuT7_Q05m2BG__Z5XpKfX6_vrr43tz--3Vx9vm1c26m1sRJGwVgvmAUlbScnKTvRa-0lMC607ZXydvDg7Ai2hWlymk_cDnJQTHvXXpIPJ99c0q_N42qWgM7PM0SfNjRCK9nWfMRQUXFCXUmIxU8ml7BA2Q1n5tiBOXVgagfmTwdGVdH7Z__NLn78J_kbegXaE4D1KR58MQ9pKzUq_J_tE5p7lmU</recordid><startdate>20231201</startdate><enddate>20231201</enddate><creator>Ahmed, Ishtkhar</creator><creator>Udawat, Harsh Prasad</creator><creator>Ansari, Mohsin</creator><creator>Yadav, Rajeev</creator><creator>Vaishnav, Sandeep</creator><creator>Agrawal, Dinesh</creator><creator>Govil, Anurag</creator><creator>Purohit, Sunita</creator><general>Springer India</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20231201</creationdate><title>Impaired gastric accommodation in patients with postprandial distress syndrome type of functional dyspepsia assessed by 2D ultrasonography</title><author>Ahmed, Ishtkhar ; Udawat, Harsh Prasad ; Ansari, Mohsin ; Yadav, Rajeev ; Vaishnav, Sandeep ; Agrawal, Dinesh ; Govil, Anurag ; Purohit, Sunita</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c347t-b5ad200620ba75b45f5542688e5a0128b677eb9eacbdab3affc81f1b959708ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Dyspepsia - diagnostic imaging</topic><topic>Gastric Emptying</topic><topic>Gastroenterology</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Original Article</topic><topic>Postprandial Period - physiology</topic><topic>Quality of Life</topic><topic>Stomach - diagnostic imaging</topic><topic>Stomach Diseases</topic><topic>Ultrasonography</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ahmed, Ishtkhar</creatorcontrib><creatorcontrib>Udawat, Harsh Prasad</creatorcontrib><creatorcontrib>Ansari, Mohsin</creatorcontrib><creatorcontrib>Yadav, Rajeev</creatorcontrib><creatorcontrib>Vaishnav, Sandeep</creatorcontrib><creatorcontrib>Agrawal, Dinesh</creatorcontrib><creatorcontrib>Govil, Anurag</creatorcontrib><creatorcontrib>Purohit, Sunita</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Indian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ahmed, Ishtkhar</au><au>Udawat, Harsh Prasad</au><au>Ansari, Mohsin</au><au>Yadav, Rajeev</au><au>Vaishnav, Sandeep</au><au>Agrawal, Dinesh</au><au>Govil, Anurag</au><au>Purohit, Sunita</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Impaired gastric accommodation in patients with postprandial distress syndrome type of functional dyspepsia assessed by 2D ultrasonography</atitle><jtitle>Indian journal of gastroenterology</jtitle><stitle>Indian J Gastroenterol</stitle><addtitle>Indian J Gastroenterol</addtitle><date>2023-12-01</date><risdate>2023</risdate><volume>42</volume><issue>6</issue><spage>824</spage><epage>832</epage><pages>824-832</pages><issn>0254-8860</issn><eissn>0975-0711</eissn><abstract>Background and Purpose
The pathophysiology of postprandial distress syndrome includes impaired gastric accommodation, hypersensitivity to gastric distension and delayed gastric emptying. 2D-ultrasonography is one of the methods to assess gastric accommodation by measuring proximal gastric area and we evaluated its role in calculating proximal gastric area and thus assessing gastric accommodation in Indian patients with postprandial distress syndrome.
Methods
In a hospital-based comparative analysis, proximal gastric area was measured with 2D-ultrasonography of postprandial distress syndrome (PDS) patients and compared with healthy controls. Five readings were measured every five minutes till 25 minutes after 400 mL of vegetable soup. The Patient Assessment of Upper Gastrointestinal Disorders-Quality of Life (PAGI-QOL score) and diets aggravating PDS symptoms were studied through detailed questionnaires. Sample size was calculated at 80% study power and alpha error of 0.05 to be 30 subjects in each group.
Results
The mean age of patients (18 males) vs. 30 healthy controls (25 males) was 40.8 ± 11.50 years vs. 36.37 ± 7.58, respectively, (
p
= 0.084). Proximal gastric area was significantly lower in patients versus healthy controls at five minutes (22.54 ± 2.77 vs. 30.66 ± 2.55 cm
2
), 10 minutes (23.03 ± 2.45 vs. 31.10 ± 2.06 cm
2
), 15 minutes (23.06 ± 2.27 vs. 30.31 ± 2.11 cm
2
), 20 minutes (22.21 ± 2.31 vs. 29.73 ± 1.71 cm
2
) and 25 minutes (22.02 ± 2.33 vs. 28.39 ± 1.55 cm
2
);
p
< 0.001 at all intervals of time, indicating impaired gastric accommodation. The QOL was poor in all patients with PDS with mean PAGI-QOL score of 31.30 ± 15.05, median of 30, minimum score of 12 and maximum score of 66.
Conclusions
Measurement of proximal gastric area with 2D-ultrasonography is simple and non-invasive. Proximal gastric area in patients was lower than controls, indicating impaired gastric accommodation. Poor quality of life was universal in patients with postprandial distress syndrome.
Graphical Abstract</abstract><cop>New Delhi</cop><pub>Springer India</pub><pmid>37814116</pmid><doi>10.1007/s12664-023-01436-7</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0254-8860 |
| ispartof | Indian journal of gastroenterology, 2023-12, Vol.42 (6), p.824-832 |
| issn | 0254-8860 0975-0711 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2875381429 |
| source | Springer Nature |
| subjects | Dyspepsia - diagnostic imaging Gastric Emptying Gastroenterology Hepatology Humans Male Medicine Medicine & Public Health Original Article Postprandial Period - physiology Quality of Life Stomach - diagnostic imaging Stomach Diseases Ultrasonography |
| title | Impaired gastric accommodation in patients with postprandial distress syndrome type of functional dyspepsia assessed by 2D ultrasonography |
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