Mini review of molecules involved in altered postnatal neurogenesis in autism

The neurobiology of autism is complex, but emerging research points to potential abnormalities and alterations in neurogenesis. The aim of the present review is to describe the advances in the understanding of the role of selected neurotrophins, neuropeptides, and other compounds secreted by neurona...

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Bibliographic Details
Published in:International journal of neuroscience 2024-12, Vol.134 (12), p.1429-15
Main Authors: Bukatova, Stanislava, Bacova, Zuzana, Osacka, Jana, Bakos, Jan
Format: Article
Language:English
Subjects:
Animals
Autistic Disorder - metabolism
Autistic Disorder - physiopathology
Humans
Nerve Growth Factors - metabolism
Neurogenesis - physiology
Neurons - metabolism
Neuropeptides - metabolism
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Summary:The neurobiology of autism is complex, but emerging research points to potential abnormalities and alterations in neurogenesis. The aim of the present review is to describe the advances in the understanding of the role of selected neurotrophins, neuropeptides, and other compounds secreted by neuronal cells in the processes of postnatal neurogenesis in conjunction with autism. We characterize the fundamental mechanisms of neuronal cell proliferation, generation of major neuronal cell types with special emphasis on neurogenic niches - the subventricular zone and hippocampal areas. We also discuss changes in intracellular calcium levels and calcium-dependent transcription factors in the context of the regulation of neurogenesis and cell fate determination. To sum up, this review provides specific insight into the known association between alterations in the function of the entire spectrum of molecules involved in neurogenesis and the etiology of autism pathogenesis.
ISSN:0020-7454
1563-5279
1563-5279
1543-5245
DOI:10.1080/00207454.2023.2269304