Organ Procurement Using Normothermic Regional Perfusion—Reply

Truog et al respond to comments on their article on organ procurement using normothermic regional perfusion. In the US, the Uniform Determination of Death Act requires either the irreversible cessation of circulatory and respiratory functions or the irreversible cessation of all functions of the ent...

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Bibliographic Details
Published in:JAMA : the journal of the American Medical Association 2023-10, Vol.330 (14), p.1390-1391
Main Authors: Truog, Robert D, Flescher, Andrew, Ladin, Keren
Format: Article
Language:English
Subjects:
Death
Mortality
Perfusion
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Summary:Truog et al respond to comments on their article on organ procurement using normothermic regional perfusion. In the US, the Uniform Determination of Death Act requires either the irreversible cessation of circulatory and respiratory functions or the irreversible cessation of all functions of the entire brain. As Drs Esbensen and Prager contend, normothermic regional perfusion neither fulfills the requirements of the law nor adheres to the dead donor rule, which requires that organ donation follow death and not contribute to it. While circulatory function temporarily ceases for the 5 minutes required by most protocols, it is restored regionally before the transplantable organs are removed, calling into question the validity of the initial death determination.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2023.16890