Sex and age differences of major cardiovascular events in patients after percutaneous coronary intervention

Women usually have higher risk after receiving percutaneous coronary interventions (PCIs) than men with coronary artery disease (CAD). The aim of this study was to investigate the association of sex differences with future outcomes in CAD patients undergoing PCI, to assess the role of age, and to ex...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Chinese Medical Association 2023-12, Vol.86 (12), p.1046-1052
Main Authors: Yang, Ya-Ling, Chen, Su-Chan, Wu, Cheng-Hsueh, Huang, Shao-Sung, Leong Chan, Wan, Lin, Shing-Jong, Chou, Chia-Yu, Chen, Jaw-Wen, Pan, Ju-Pin, Charng, Min-Ji, Chen, Ying-Hwa, Wu, Tao-Cheng, Lu, Tse-Min, Hsu, Pai-Feng, Huang, Po-Hsun, Cheng, Hao-Min, Huang, Chin-Chou, Sung, Shih-Hsien, Lin, Yenn-Jiang, Leu, Hsin-Bang
Format: Article
Language:English
Subjects:
Coronary Artery Disease - etiology
Death
Female
Heart Failure
Humans
Male
Percutaneous Coronary Intervention - adverse effects
Risk Factors
Stroke - etiology
Treatment Outcome
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Women usually have higher risk after receiving percutaneous coronary interventions (PCIs) than men with coronary artery disease (CAD). The aim of this study was to investigate the association of sex differences with future outcomes in CAD patients undergoing PCI, to assess the role of age, and to extend observed endpoints to stroke and congestive heart failure. Six thousand six hundred forty-seven patients with CAD who received successful PCIs. The associations between clinic outcomes and sex were analyzed. The primary outcome was major cardiovascular events (MACE), including cardiac death, nonfatal myocardial infraction, and nonfatal stroke. The secondary outcome was MACE and hospitalization for heart failure (total CV events). During a mean of 52.7 months of follow-up, 4833 men and 1614 women received PCI. Univariate and multivariate analyses showed that women were independently associated with an increased risk of cardiac death (HR, 1.78; 95% CI, 1.32-2.41), hospitalization for heart failure (HR, 1.53; 95% CI, 1.23-1.89), MACE (HR, 1.34; 95% CI, 1.10-1.63), and total CV events (HR, 1.39; 95% CI, 1.20-1.62). In the subgroup analysis, women aged under 60 years had higher cardiovascular risks than men of the same age category. Women with CAD after successful PCI had poorer cardiovascular outcomes than men. Additionally, younger women (aged
ISSN:1726-4901
1728-7731
DOI:10.1097/JCMA.0000000000001011