Wnt signaling in periodontitis

Objective This study aimed to evaluate the Wnt/β-catenin signaling pathway activity in gingival samples obtained from patients with periodontitis. Materials and methods Fifteen patients with stage III grade B (SIIIGB) and eleven with stage III grade C (SIIIGC) periodontitis were included and compare...

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Published in:Clinical oral investigations 2023-11, Vol.27 (11), p.6801-6812
Main Authors: Güney, Zeliha, Kurgan, Şivge, Önder, Canan, Tayman, Mahmure Ayşe, Günhan, Ömer, Kantarci, Alpdoğan, Serdar, Muhittin Abdulkadir, Günhan, Meral
Format: Article
Language:English
Subjects:
beta Catenin - metabolism
Biofilms
Biopsy
Connective tissue
Dentistry
Genes
Gingiva - metabolism
Gum disease
Homeostasis
Humans
Inflammation
Inflammation - metabolism
Medicine
Periodontics
Periodontitis
Periodontitis - metabolism
Signal transduction
Systemic diseases
Teeth
Transcription factors
Wnt protein
Wnt Signaling Pathway
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Summary:Objective This study aimed to evaluate the Wnt/β-catenin signaling pathway activity in gingival samples obtained from patients with periodontitis. Materials and methods Fifteen patients with stage III grade B (SIIIGB) and eleven with stage III grade C (SIIIGC) periodontitis were included and compared to 15 control subjects. β-Catenin, Wnt 3a, Wnt 5a, and Wnt 10b expressions were evaluated by Q-PCR. Topographic localization of tissue β-catenin, Wnt 5a, and Wnt 10b was measured by immunohistochemical analysis. TNF-α was used to assess the inflammatory state of the tissues, while Runx2 was used as a mediator of active destruction. Results Wnt 3a, Wnt 5a, and Wnt 10b were significantly higher in gingival tissues in both grades of stage 3 periodontitis compared to the control group ( p  
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-023-05294-7