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Retrospective evaluation of Guillain‐Barre syndrome in children: A single‐center experience
Background Although Guillain‐Barré syndrome (GBS) is now the most common cause of acute flaccid paralysis in children, information on the long‐term follow‐up of GBS is still limited. Identification of prognostic factors can play an important role in treatment strategies and the follow‐up of patients...
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| Published in: | Pediatrics international 2023-01, Vol.65 (1), p.e15650-n/a |
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| creator | Güzin, Yiğithan Yılmaz, Unsal Pekuz, Serdar Karaoğlu, Pakize Parlak İbiş, İpek Burcu Kırkgöz, Hatice Hilal Yavuz, Merve Ünalp, Aycan |
| description | Background
Although Guillain‐Barré syndrome (GBS) is now the most common cause of acute flaccid paralysis in children, information on the long‐term follow‐up of GBS is still limited. Identification of prognostic factors can play an important role in treatment strategies and the follow‐up of patients. This study aimed to evaluate the effectiveness of monitoring the GBS disability score (DS) in predicting morbidity and mortality.
Methods
The patients were separated into two groups those with DS≥ or |
| doi_str_mv | 10.1111/ped.15650 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2875851618</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2875851618</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3130-152511374fe7eb8806b6985212e5ffa43b10caa34df08b85efd7bad05e861c6d3</originalsourceid><addsrcrecordid>eNp1kMFO3DAQhi1EBXTLgRdAkbjAIcvYiWPT23aBLdJKoKqVuBnHmYBR1kntZOne-gh9BJ6FR-mT1LBwqcRcZjT69OvXR8gehTGNc9xhNaa84LBBdmies5QBXG_GO2MylVCIbfIxhHsAkELmW2Q7E5KKHPIdcvMNe9-GDk1vl5jgUjeD7m3rkrZOZoNtGm3d399_vmjvMQkrV_l2gYl1ibmzTeXRfU4mT4_ButsGI2fQ9egT_NWht-gMfiIfat0E3H3dI_Lj_Oz79Gs6v5xdTCfz1GQ0g5RyxinNRF6jwFLG0mVxIjmjDHld6zwrKRits7yqQZaSY12JUlfAURbUFFU2Iofr3M63PwcMvVrYYDD2d9gOQTEpuOS0oDKiB_-h9-3gXWyn2AkUTEgBEKmjNWWin-CxVp23C-1XioJ61q6idvWiPbL7r4lDuYjfN_LNcwSO18CDbXD1fpK6OjtdR_4DQ7mO6g</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2906278700</pqid></control><display><type>article</type><title>Retrospective evaluation of Guillain‐Barre syndrome in children: A single‐center experience</title><source>Wiley-Blackwell Read & Publish Collection</source><creator>Güzin, Yiğithan ; Yılmaz, Unsal ; Pekuz, Serdar ; Karaoğlu, Pakize ; Parlak İbiş, İpek Burcu ; Kırkgöz, Hatice Hilal ; Yavuz, Merve ; Ünalp, Aycan</creator><creatorcontrib>Güzin, Yiğithan ; Yılmaz, Unsal ; Pekuz, Serdar ; Karaoğlu, Pakize ; Parlak İbiş, İpek Burcu ; Kırkgöz, Hatice Hilal ; Yavuz, Merve ; Ünalp, Aycan</creatorcontrib><description>Background
Although Guillain‐Barré syndrome (GBS) is now the most common cause of acute flaccid paralysis in children, information on the long‐term follow‐up of GBS is still limited. Identification of prognostic factors can play an important role in treatment strategies and the follow‐up of patients. This study aimed to evaluate the effectiveness of monitoring the GBS disability score (DS) in predicting morbidity and mortality.
Methods
The patients were separated into two groups those with DS≥ or <3 on admission. These groups were compared in respect of demographic data, clinical and laboratory findings, and the DS recorded on admission and at first, third, sixth, 12th, and 24th months.
Results
The study included 44 patients (54.5% male, 45.5% female) with a median age of 5 years. The most common involvements during the disease were weakness, ataxia, neuropathic pain, cranial neuropathy, respiratory distress, autonomic dysfunction, and psychiatric symptoms, respectively. In patients with a DS of ≥3, the time from onset of symptoms to hospital admission was shorter, and the length of hospital stay was longer. Children with back pain and autonomic dysfunction had a DS of ≥3. A high 3‐month DS was found to be a significant predictor for the development of sequelae.
Conclusions
Although progressive muscle weakness and inability to walk are the most common symptoms of GBS, it should be kept in mind that atypical manifestations such as hemiplegia and ophthalmoplegia may also occur. For an objective assessment of clinical improvement during follow‐up, the DS for motor functions can be used.</description><identifier>ISSN: 1328-8067</identifier><identifier>EISSN: 1442-200X</identifier><identifier>DOI: 10.1111/ped.15650</identifier><identifier>PMID: 37817404</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Ataxia ; Autonomic nervous system ; Child ; Child, Preschool ; Children ; Complications ; disability score ; Disease Progression ; Female ; Guillain-Barre syndrome ; Guillain-Barre Syndrome - diagnosis ; Guillain-Barre Syndrome - therapy ; Hemiplegia ; Hospitalization ; Humans ; Length of Stay ; long‐term prognosis ; Male ; Morbidity ; Neuropathy ; Ophthalmoplegia ; Paralysis ; Patients ; Pediatrics ; Retrospective Studies</subject><ispartof>Pediatrics international, 2023-01, Vol.65 (1), p.e15650-n/a</ispartof><rights>2023 Japan Pediatric Society.</rights><rights>2023 Japan Pediatric Society</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3130-152511374fe7eb8806b6985212e5ffa43b10caa34df08b85efd7bad05e861c6d3</cites><orcidid>0000-0002-7256-8557 ; 0000-0002-0866-3947 ; 0000-0002-8748-5586 ; 0000-0003-2014-8822 ; 0000-0002-7143-0943 ; 0000-0003-1098-7024 ; 0000-0002-3611-5059</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37817404$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Güzin, Yiğithan</creatorcontrib><creatorcontrib>Yılmaz, Unsal</creatorcontrib><creatorcontrib>Pekuz, Serdar</creatorcontrib><creatorcontrib>Karaoğlu, Pakize</creatorcontrib><creatorcontrib>Parlak İbiş, İpek Burcu</creatorcontrib><creatorcontrib>Kırkgöz, Hatice Hilal</creatorcontrib><creatorcontrib>Yavuz, Merve</creatorcontrib><creatorcontrib>Ünalp, Aycan</creatorcontrib><title>Retrospective evaluation of Guillain‐Barre syndrome in children: A single‐center experience</title><title>Pediatrics international</title><addtitle>Pediatr Int</addtitle><description>Background
Although Guillain‐Barré syndrome (GBS) is now the most common cause of acute flaccid paralysis in children, information on the long‐term follow‐up of GBS is still limited. Identification of prognostic factors can play an important role in treatment strategies and the follow‐up of patients. This study aimed to evaluate the effectiveness of monitoring the GBS disability score (DS) in predicting morbidity and mortality.
Methods
The patients were separated into two groups those with DS≥ or <3 on admission. These groups were compared in respect of demographic data, clinical and laboratory findings, and the DS recorded on admission and at first, third, sixth, 12th, and 24th months.
Results
The study included 44 patients (54.5% male, 45.5% female) with a median age of 5 years. The most common involvements during the disease were weakness, ataxia, neuropathic pain, cranial neuropathy, respiratory distress, autonomic dysfunction, and psychiatric symptoms, respectively. In patients with a DS of ≥3, the time from onset of symptoms to hospital admission was shorter, and the length of hospital stay was longer. Children with back pain and autonomic dysfunction had a DS of ≥3. A high 3‐month DS was found to be a significant predictor for the development of sequelae.
Conclusions
Although progressive muscle weakness and inability to walk are the most common symptoms of GBS, it should be kept in mind that atypical manifestations such as hemiplegia and ophthalmoplegia may also occur. For an objective assessment of clinical improvement during follow‐up, the DS for motor functions can be used.</description><subject>Ataxia</subject><subject>Autonomic nervous system</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children</subject><subject>Complications</subject><subject>disability score</subject><subject>Disease Progression</subject><subject>Female</subject><subject>Guillain-Barre syndrome</subject><subject>Guillain-Barre Syndrome - diagnosis</subject><subject>Guillain-Barre Syndrome - therapy</subject><subject>Hemiplegia</subject><subject>Hospitalization</subject><subject>Humans</subject><subject>Length of Stay</subject><subject>long‐term prognosis</subject><subject>Male</subject><subject>Morbidity</subject><subject>Neuropathy</subject><subject>Ophthalmoplegia</subject><subject>Paralysis</subject><subject>Patients</subject><subject>Pediatrics</subject><subject>Retrospective Studies</subject><issn>1328-8067</issn><issn>1442-200X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp1kMFO3DAQhi1EBXTLgRdAkbjAIcvYiWPT23aBLdJKoKqVuBnHmYBR1kntZOne-gh9BJ6FR-mT1LBwqcRcZjT69OvXR8gehTGNc9xhNaa84LBBdmies5QBXG_GO2MylVCIbfIxhHsAkELmW2Q7E5KKHPIdcvMNe9-GDk1vl5jgUjeD7m3rkrZOZoNtGm3d399_vmjvMQkrV_l2gYl1ibmzTeXRfU4mT4_ButsGI2fQ9egT_NWht-gMfiIfat0E3H3dI_Lj_Oz79Gs6v5xdTCfz1GQ0g5RyxinNRF6jwFLG0mVxIjmjDHld6zwrKRits7yqQZaSY12JUlfAURbUFFU2Iofr3M63PwcMvVrYYDD2d9gOQTEpuOS0oDKiB_-h9-3gXWyn2AkUTEgBEKmjNWWin-CxVp23C-1XioJ61q6idvWiPbL7r4lDuYjfN_LNcwSO18CDbXD1fpK6OjtdR_4DQ7mO6g</recordid><startdate>202301</startdate><enddate>202301</enddate><creator>Güzin, Yiğithan</creator><creator>Yılmaz, Unsal</creator><creator>Pekuz, Serdar</creator><creator>Karaoğlu, Pakize</creator><creator>Parlak İbiş, İpek Burcu</creator><creator>Kırkgöz, Hatice Hilal</creator><creator>Yavuz, Merve</creator><creator>Ünalp, Aycan</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7256-8557</orcidid><orcidid>https://orcid.org/0000-0002-0866-3947</orcidid><orcidid>https://orcid.org/0000-0002-8748-5586</orcidid><orcidid>https://orcid.org/0000-0003-2014-8822</orcidid><orcidid>https://orcid.org/0000-0002-7143-0943</orcidid><orcidid>https://orcid.org/0000-0003-1098-7024</orcidid><orcidid>https://orcid.org/0000-0002-3611-5059</orcidid></search><sort><creationdate>202301</creationdate><title>Retrospective evaluation of Guillain‐Barre syndrome in children: A single‐center experience</title><author>Güzin, Yiğithan ; Yılmaz, Unsal ; Pekuz, Serdar ; Karaoğlu, Pakize ; Parlak İbiş, İpek Burcu ; Kırkgöz, Hatice Hilal ; Yavuz, Merve ; Ünalp, Aycan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3130-152511374fe7eb8806b6985212e5ffa43b10caa34df08b85efd7bad05e861c6d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Ataxia</topic><topic>Autonomic nervous system</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children</topic><topic>Complications</topic><topic>disability score</topic><topic>Disease Progression</topic><topic>Female</topic><topic>Guillain-Barre syndrome</topic><topic>Guillain-Barre Syndrome - diagnosis</topic><topic>Guillain-Barre Syndrome - therapy</topic><topic>Hemiplegia</topic><topic>Hospitalization</topic><topic>Humans</topic><topic>Length of Stay</topic><topic>long‐term prognosis</topic><topic>Male</topic><topic>Morbidity</topic><topic>Neuropathy</topic><topic>Ophthalmoplegia</topic><topic>Paralysis</topic><topic>Patients</topic><topic>Pediatrics</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Güzin, Yiğithan</creatorcontrib><creatorcontrib>Yılmaz, Unsal</creatorcontrib><creatorcontrib>Pekuz, Serdar</creatorcontrib><creatorcontrib>Karaoğlu, Pakize</creatorcontrib><creatorcontrib>Parlak İbiş, İpek Burcu</creatorcontrib><creatorcontrib>Kırkgöz, Hatice Hilal</creatorcontrib><creatorcontrib>Yavuz, Merve</creatorcontrib><creatorcontrib>Ünalp, Aycan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Güzin, Yiğithan</au><au>Yılmaz, Unsal</au><au>Pekuz, Serdar</au><au>Karaoğlu, Pakize</au><au>Parlak İbiş, İpek Burcu</au><au>Kırkgöz, Hatice Hilal</au><au>Yavuz, Merve</au><au>Ünalp, Aycan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Retrospective evaluation of Guillain‐Barre syndrome in children: A single‐center experience</atitle><jtitle>Pediatrics international</jtitle><addtitle>Pediatr Int</addtitle><date>2023-01</date><risdate>2023</risdate><volume>65</volume><issue>1</issue><spage>e15650</spage><epage>n/a</epage><pages>e15650-n/a</pages><issn>1328-8067</issn><eissn>1442-200X</eissn><abstract>Background
Although Guillain‐Barré syndrome (GBS) is now the most common cause of acute flaccid paralysis in children, information on the long‐term follow‐up of GBS is still limited. Identification of prognostic factors can play an important role in treatment strategies and the follow‐up of patients. This study aimed to evaluate the effectiveness of monitoring the GBS disability score (DS) in predicting morbidity and mortality.
Methods
The patients were separated into two groups those with DS≥ or <3 on admission. These groups were compared in respect of demographic data, clinical and laboratory findings, and the DS recorded on admission and at first, third, sixth, 12th, and 24th months.
Results
The study included 44 patients (54.5% male, 45.5% female) with a median age of 5 years. The most common involvements during the disease were weakness, ataxia, neuropathic pain, cranial neuropathy, respiratory distress, autonomic dysfunction, and psychiatric symptoms, respectively. In patients with a DS of ≥3, the time from onset of symptoms to hospital admission was shorter, and the length of hospital stay was longer. Children with back pain and autonomic dysfunction had a DS of ≥3. A high 3‐month DS was found to be a significant predictor for the development of sequelae.
Conclusions
Although progressive muscle weakness and inability to walk are the most common symptoms of GBS, it should be kept in mind that atypical manifestations such as hemiplegia and ophthalmoplegia may also occur. For an objective assessment of clinical improvement during follow‐up, the DS for motor functions can be used.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>37817404</pmid><doi>10.1111/ped.15650</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7256-8557</orcidid><orcidid>https://orcid.org/0000-0002-0866-3947</orcidid><orcidid>https://orcid.org/0000-0002-8748-5586</orcidid><orcidid>https://orcid.org/0000-0003-2014-8822</orcidid><orcidid>https://orcid.org/0000-0002-7143-0943</orcidid><orcidid>https://orcid.org/0000-0003-1098-7024</orcidid><orcidid>https://orcid.org/0000-0002-3611-5059</orcidid></addata></record> |
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| ispartof | Pediatrics international, 2023-01, Vol.65 (1), p.e15650-n/a |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Ataxia Autonomic nervous system Child Child, Preschool Children Complications disability score Disease Progression Female Guillain-Barre syndrome Guillain-Barre Syndrome - diagnosis Guillain-Barre Syndrome - therapy Hemiplegia Hospitalization Humans Length of Stay long‐term prognosis Male Morbidity Neuropathy Ophthalmoplegia Paralysis Patients Pediatrics Retrospective Studies |
| title | Retrospective evaluation of Guillain‐Barre syndrome in children: A single‐center experience |
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