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Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection
Purpose We sought to compare the effectiveness of a novel antibiotic irrigation device to the standard O-ring wound retractor in preventing surgical site infections (SSIs) following colorectal resections. Methods This single-arm clinical trial included patients undergoing colorectal resections utili...
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| Published in: | International journal of colorectal disease 2023-10, Vol.38 (1), p.252-252, Article 252 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 252 |
| container_issue | 1 |
| container_start_page | 252 |
| container_title | International journal of colorectal disease |
| container_volume | 38 |
| creator | Nasseri, Yosef Kasheri, Eli Zhu, Ruoyan Smiley, Abbas Cohen, Jason Ellenhorn, Joshua Barnajian, Moshe Oka, Kimberly |
| description | Purpose
We sought to compare the effectiveness of a novel antibiotic irrigation device to the standard O-ring wound retractor in preventing surgical site infections (SSIs) following colorectal resections.
Methods
This single-arm clinical trial included patients undergoing colorectal resections utilizing the novel device. A retrospective cohort of patients undergoing the same procedures with the O-ring retractor was selected as the control group. The primary outcome assessed was SSI. Secondary outcomes assessed were overall complications, hospital length of stay (LOS), and 30-day readmission. A univariable and multivariable logistic regression model was built to evaluate the association between SSI as the outcome variable and the use of the novel device as the main independent variable. The model was adjusted for any confounding variables.
Results
Eighty-six novel device cases and 170 O-ring retractor cases were enrolled. There were no significant differences between the two groups in terms of demographics and preoperative comorbidities. Cases with the novel device had fewer Pfannenstiel incisions (1.2% vs. 14.6%,
p
|
| doi_str_mv | 10.1007/s00384-023-04542-2 |
| format | article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_2876635453</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A768628192</galeid><sourcerecordid>A768628192</sourcerecordid><originalsourceid>FETCH-LOGICAL-c365t-2f669e12f04b524c7019b91d4e398cc7cde71c20880f7ca396fa5f8f0c0f009e3</originalsourceid><addsrcrecordid>eNp9kc1u1TAQhSMEoqXwAiyQJTZsUvyT2MmyqvipVNENrC1fZ3xx5Wtfxs6t-iC8L85NqUBCyAtbM9858sxpmteMnjNK1ftMqRi6lnLR0q7veMufNKesE7xlXPKnf7xPmhc531LKlFTd8-ZEqIGNvVCnzc8v6QCBmFj8xqfiLfGIfmuKT5FMcPAWyAEwz5nkYuJkcCI3Lfq4JXdpjhNBKGhsSUh8JOU7kD3CAeJRnxzJM269NYFkX6AiDuyx5VII6W6xsSkkrNXKIOS1_bJ55kzI8OrhPmu-ffzw9fJze33z6ery4rq1Qval5U7KERh3tNv0vLOKsnEzsqkDMQ7WKjuBYpbTYaBOWSNG6UzvBkctdZSOIM6ad6vvHtOPGXLRO58thGAipDlrPigpRd_1oqJvV3RrAug6SFrmXnB9oeQged0or9T5P6h6Jth5myI4X-t_CfgqsJhyRnB6j35n8F4zqpeU9ZqyrinrY8p6Eb15-Pa82cH0KPkdawXECuT9EhWgvk0zxrrK_9n-AizztRE</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2876635453</pqid></control><display><type>article</type><title>Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection</title><source>Springer Link</source><creator>Nasseri, Yosef ; Kasheri, Eli ; Zhu, Ruoyan ; Smiley, Abbas ; Cohen, Jason ; Ellenhorn, Joshua ; Barnajian, Moshe ; Oka, Kimberly</creator><creatorcontrib>Nasseri, Yosef ; Kasheri, Eli ; Zhu, Ruoyan ; Smiley, Abbas ; Cohen, Jason ; Ellenhorn, Joshua ; Barnajian, Moshe ; Oka, Kimberly</creatorcontrib><description>Purpose
We sought to compare the effectiveness of a novel antibiotic irrigation device to the standard O-ring wound retractor in preventing surgical site infections (SSIs) following colorectal resections.
Methods
This single-arm clinical trial included patients undergoing colorectal resections utilizing the novel device. A retrospective cohort of patients undergoing the same procedures with the O-ring retractor was selected as the control group. The primary outcome assessed was SSI. Secondary outcomes assessed were overall complications, hospital length of stay (LOS), and 30-day readmission. A univariable and multivariable logistic regression model was built to evaluate the association between SSI as the outcome variable and the use of the novel device as the main independent variable. The model was adjusted for any confounding variables.
Results
Eighty-six novel device cases and 170 O-ring retractor cases were enrolled. There were no significant differences between the two groups in terms of demographics and preoperative comorbidities. Cases with the novel device had fewer Pfannenstiel incisions (1.2% vs. 14.6%,
p
< 0.001). There were no other significant differences in intraoperative variables. SSI rates were significantly lower in the novel device group (1.2% vs. 9.1%,
p
= 0.014). There were no other significant differences in postoperative complications. Multivariable logistic regression with backward elimination showed that the use of the novel device was significantly more effective against SSI by 92.5% compared to the use of the O-ring retractor.
Conclusion
The novel device may contribute to lower SSI rates compared to the O-ring retractor following colorectal resection.</description><identifier>ISSN: 1432-1262</identifier><identifier>ISSN: 0179-1958</identifier><identifier>EISSN: 1432-1262</identifier><identifier>DOI: 10.1007/s00384-023-04542-2</identifier><identifier>PMID: 37819537</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Analysis ; Anti-Bacterial Agents - therapeutic use ; Colorectal Neoplasms - complications ; Comorbidity ; Gastroenterology ; Health aspects ; Hepatology ; Humans ; Infection ; Infection control ; Internal Medicine ; Medicine ; Medicine & Public Health ; Metronidazole ; Neomycin ; Prevention ; Proctology ; Retrospective Studies ; Surgery ; Surgical Wound Infection - epidemiology ; Surgical Wound Infection - etiology ; Surgical Wound Infection - prevention & control</subject><ispartof>International journal of colorectal disease, 2023-10, Vol.38 (1), p.252-252, Article 252</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>COPYRIGHT 2023 Springer</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c365t-2f669e12f04b524c7019b91d4e398cc7cde71c20880f7ca396fa5f8f0c0f009e3</cites><orcidid>0000-0003-0590-0553 ; 0000-0001-8057-6488 ; 0000-0001-9576-4457 ; 0000-0002-9186-5717</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/37819537$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nasseri, Yosef</creatorcontrib><creatorcontrib>Kasheri, Eli</creatorcontrib><creatorcontrib>Zhu, Ruoyan</creatorcontrib><creatorcontrib>Smiley, Abbas</creatorcontrib><creatorcontrib>Cohen, Jason</creatorcontrib><creatorcontrib>Ellenhorn, Joshua</creatorcontrib><creatorcontrib>Barnajian, Moshe</creatorcontrib><creatorcontrib>Oka, Kimberly</creatorcontrib><title>Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection</title><title>International journal of colorectal disease</title><addtitle>Int J Colorectal Dis</addtitle><addtitle>Int J Colorectal Dis</addtitle><description>Purpose
We sought to compare the effectiveness of a novel antibiotic irrigation device to the standard O-ring wound retractor in preventing surgical site infections (SSIs) following colorectal resections.
Methods
This single-arm clinical trial included patients undergoing colorectal resections utilizing the novel device. A retrospective cohort of patients undergoing the same procedures with the O-ring retractor was selected as the control group. The primary outcome assessed was SSI. Secondary outcomes assessed were overall complications, hospital length of stay (LOS), and 30-day readmission. A univariable and multivariable logistic regression model was built to evaluate the association between SSI as the outcome variable and the use of the novel device as the main independent variable. The model was adjusted for any confounding variables.
Results
Eighty-six novel device cases and 170 O-ring retractor cases were enrolled. There were no significant differences between the two groups in terms of demographics and preoperative comorbidities. Cases with the novel device had fewer Pfannenstiel incisions (1.2% vs. 14.6%,
p
< 0.001). There were no other significant differences in intraoperative variables. SSI rates were significantly lower in the novel device group (1.2% vs. 9.1%,
p
= 0.014). There were no other significant differences in postoperative complications. Multivariable logistic regression with backward elimination showed that the use of the novel device was significantly more effective against SSI by 92.5% compared to the use of the O-ring retractor.
Conclusion
The novel device may contribute to lower SSI rates compared to the O-ring retractor following colorectal resection.</description><subject>Analysis</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Colorectal Neoplasms - complications</subject><subject>Comorbidity</subject><subject>Gastroenterology</subject><subject>Health aspects</subject><subject>Hepatology</subject><subject>Humans</subject><subject>Infection</subject><subject>Infection control</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metronidazole</subject><subject>Neomycin</subject><subject>Prevention</subject><subject>Proctology</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><subject>Surgical Wound Infection - epidemiology</subject><subject>Surgical Wound Infection - etiology</subject><subject>Surgical Wound Infection - prevention & control</subject><issn>1432-1262</issn><issn>0179-1958</issn><issn>1432-1262</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNp9kc1u1TAQhSMEoqXwAiyQJTZsUvyT2MmyqvipVNENrC1fZ3xx5Wtfxs6t-iC8L85NqUBCyAtbM9858sxpmteMnjNK1ftMqRi6lnLR0q7veMufNKesE7xlXPKnf7xPmhc531LKlFTd8-ZEqIGNvVCnzc8v6QCBmFj8xqfiLfGIfmuKT5FMcPAWyAEwz5nkYuJkcCI3Lfq4JXdpjhNBKGhsSUh8JOU7kD3CAeJRnxzJM269NYFkX6AiDuyx5VII6W6xsSkkrNXKIOS1_bJ55kzI8OrhPmu-ffzw9fJze33z6ery4rq1Qval5U7KERh3tNv0vLOKsnEzsqkDMQ7WKjuBYpbTYaBOWSNG6UzvBkctdZSOIM6ad6vvHtOPGXLRO58thGAipDlrPigpRd_1oqJvV3RrAug6SFrmXnB9oeQged0or9T5P6h6Jth5myI4X-t_CfgqsJhyRnB6j35n8F4zqpeU9ZqyrinrY8p6Eb15-Pa82cH0KPkdawXECuT9EhWgvk0zxrrK_9n-AizztRE</recordid><startdate>20231011</startdate><enddate>20231011</enddate><creator>Nasseri, Yosef</creator><creator>Kasheri, Eli</creator><creator>Zhu, Ruoyan</creator><creator>Smiley, Abbas</creator><creator>Cohen, Jason</creator><creator>Ellenhorn, Joshua</creator><creator>Barnajian, Moshe</creator><creator>Oka, Kimberly</creator><general>Springer Berlin Heidelberg</general><general>Springer</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0590-0553</orcidid><orcidid>https://orcid.org/0000-0001-8057-6488</orcidid><orcidid>https://orcid.org/0000-0001-9576-4457</orcidid><orcidid>https://orcid.org/0000-0002-9186-5717</orcidid></search><sort><creationdate>20231011</creationdate><title>Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection</title><author>Nasseri, Yosef ; Kasheri, Eli ; Zhu, Ruoyan ; Smiley, Abbas ; Cohen, Jason ; Ellenhorn, Joshua ; Barnajian, Moshe ; Oka, Kimberly</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c365t-2f669e12f04b524c7019b91d4e398cc7cde71c20880f7ca396fa5f8f0c0f009e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Analysis</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Colorectal Neoplasms - complications</topic><topic>Comorbidity</topic><topic>Gastroenterology</topic><topic>Health aspects</topic><topic>Hepatology</topic><topic>Humans</topic><topic>Infection</topic><topic>Infection control</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metronidazole</topic><topic>Neomycin</topic><topic>Prevention</topic><topic>Proctology</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><topic>Surgical Wound Infection - epidemiology</topic><topic>Surgical Wound Infection - etiology</topic><topic>Surgical Wound Infection - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nasseri, Yosef</creatorcontrib><creatorcontrib>Kasheri, Eli</creatorcontrib><creatorcontrib>Zhu, Ruoyan</creatorcontrib><creatorcontrib>Smiley, Abbas</creatorcontrib><creatorcontrib>Cohen, Jason</creatorcontrib><creatorcontrib>Ellenhorn, Joshua</creatorcontrib><creatorcontrib>Barnajian, Moshe</creatorcontrib><creatorcontrib>Oka, Kimberly</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of colorectal disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nasseri, Yosef</au><au>Kasheri, Eli</au><au>Zhu, Ruoyan</au><au>Smiley, Abbas</au><au>Cohen, Jason</au><au>Ellenhorn, Joshua</au><au>Barnajian, Moshe</au><au>Oka, Kimberly</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection</atitle><jtitle>International journal of colorectal disease</jtitle><stitle>Int J Colorectal Dis</stitle><addtitle>Int J Colorectal Dis</addtitle><date>2023-10-11</date><risdate>2023</risdate><volume>38</volume><issue>1</issue><spage>252</spage><epage>252</epage><pages>252-252</pages><artnum>252</artnum><issn>1432-1262</issn><issn>0179-1958</issn><eissn>1432-1262</eissn><abstract>Purpose
We sought to compare the effectiveness of a novel antibiotic irrigation device to the standard O-ring wound retractor in preventing surgical site infections (SSIs) following colorectal resections.
Methods
This single-arm clinical trial included patients undergoing colorectal resections utilizing the novel device. A retrospective cohort of patients undergoing the same procedures with the O-ring retractor was selected as the control group. The primary outcome assessed was SSI. Secondary outcomes assessed were overall complications, hospital length of stay (LOS), and 30-day readmission. A univariable and multivariable logistic regression model was built to evaluate the association between SSI as the outcome variable and the use of the novel device as the main independent variable. The model was adjusted for any confounding variables.
Results
Eighty-six novel device cases and 170 O-ring retractor cases were enrolled. There were no significant differences between the two groups in terms of demographics and preoperative comorbidities. Cases with the novel device had fewer Pfannenstiel incisions (1.2% vs. 14.6%,
p
< 0.001). There were no other significant differences in intraoperative variables. SSI rates were significantly lower in the novel device group (1.2% vs. 9.1%,
p
= 0.014). There were no other significant differences in postoperative complications. Multivariable logistic regression with backward elimination showed that the use of the novel device was significantly more effective against SSI by 92.5% compared to the use of the O-ring retractor.
Conclusion
The novel device may contribute to lower SSI rates compared to the O-ring retractor following colorectal resection.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>37819537</pmid><doi>10.1007/s00384-023-04542-2</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0003-0590-0553</orcidid><orcidid>https://orcid.org/0000-0001-8057-6488</orcidid><orcidid>https://orcid.org/0000-0001-9576-4457</orcidid><orcidid>https://orcid.org/0000-0002-9186-5717</orcidid></addata></record> |
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| ispartof | International journal of colorectal disease, 2023-10, Vol.38 (1), p.252-252, Article 252 |
| issn | 1432-1262 0179-1958 1432-1262 |
| language | eng |
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| subjects | Analysis Anti-Bacterial Agents - therapeutic use Colorectal Neoplasms - complications Comorbidity Gastroenterology Health aspects Hepatology Humans Infection Infection control Internal Medicine Medicine Medicine & Public Health Metronidazole Neomycin Prevention Proctology Retrospective Studies Surgery Surgical Wound Infection - epidemiology Surgical Wound Infection - etiology Surgical Wound Infection - prevention & control |
| title | Novel antibiotic irrigation device versus standard O-ring wound retractor in the prevention of surgical site infection following colorectal resection |
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