Biokinetic model analysis with DTPA administration for a case of accidental inhalation of actinides in Japan

Abstract Accidental inhalation intake of plutonium isotopes and 241Am occurred at a Pu research facility in Japan in 2017, and the five workers involved in this accident were treated by the administration of Ca/Zn-diethylenetriaminepentaacetic acid (DTPA). For the worker who was most internally expo...

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Bibliographic Details
Published in:Radiation protection dosimetry 2023-10, Vol.199 (15-16), p.2025-2029
Main Authors: Tani, Kotaro, Ishigure, Nobuhito, Kim, Eunjoo, Tominaga, Takako, Tatsuzaki, Hideo, Akashi, Makoto, Kurihara, Osamu
Format: Article
Language:English
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Summary:Abstract Accidental inhalation intake of plutonium isotopes and 241Am occurred at a Pu research facility in Japan in 2017, and the five workers involved in this accident were treated by the administration of Ca/Zn-diethylenetriaminepentaacetic acid (DTPA). For the worker who was most internally exposed, the therapy was continued over 1 y after the accident. Urinary samples collected before and after each administration were subject to bioassay to evaluate the efficacy of the dose reduction. This study performed numerical analyses using a biokinetic model dealing with 241Am-DTPA with reference to the European Coordinated Network on Radiation Dosimetry approach, which assumes that the complex of actinides and Ca/Zn-DTPA is generated in the designated compartments in the biokinetic model. The results of the model prediction well captured the trend of the observed urinary excretion in the long-term bioassay and would be useful to evaluate the efficacy of the Ca/Zn-DTPA administration for the worker involved in the accident.
ISSN:0144-8420
1742-3406
DOI:10.1093/rpd/ncac224