Risk factors for T‐cell lymphopenia in frequent platelet donors: The BEST collaborative study

Background Severe T‐cell lymphopenia of uncertain clinical significance has been observed in frequent apheresis platelet donors. Two commonly used plateletpheresis instruments are the Trima Accel, which uses a leukoreduction system (LRS) chamber to trap leukocytes and the Fenwal Amicus, which does n...

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Bibliographic Details
Published in:Transfusion (Philadelphia, Pa.) Pa.), 2023-11, Vol.63 (11), p.2072-2082
Main Authors: Kaufman, Richard M., Marks, Denese C., Flamand, Yael, Acker, Jason P., Brown, Bethany L., Olafson, Carly, Marschner, Susanne, Pandey, Suchitra, Papari, Mona, Petraszko, Tanya, Serrano, Katherine, Ward, Dawn, Bazin, Renée
Format: Article
Language:English
Subjects:
Apheresis
Blood
Blood & organ donations
Blood Donors
Blood Platelets
CD4 antigen
Chambers
donors
hematology—white cells
Humans
immunology (other than RBC serology)
Leukocytes
Lymphocytes
Lymphopenia
Lymphopenia - etiology
Observational studies
Plasma
Plateletpheresis - methods
Platelets
Population studies
Risk factors
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Summary:Background Severe T‐cell lymphopenia of uncertain clinical significance has been observed in frequent apheresis platelet donors. Two commonly used plateletpheresis instruments are the Trima Accel, which uses a leukoreduction system (LRS) chamber to trap leukocytes and the Fenwal Amicus, which does not use an LRS chamber. Study Design and Methods We performed an international, multicenter, observational study comparing T‐cell populations in frequent platelet donors collected exclusively using the Trima instrument (n = 131) or the Amicus instrument (n = 77). Age‐ and sex‐matched whole blood donors (n = 126) served as controls. Results CD4+ T‐cell counts
ISSN:0041-1132
1537-2995
DOI:10.1111/trf.17567