Mechanochemistry for Healthcare: Revealing the Nitroso Derivatives Genesis in the Solid State

Nitroso derivatives with unique characteristics have been extensively studied in various fields, including biology and clinical research. Although there has been substantial investigation of “nitrosable” components in many drugs and commonly consumed nutrients, there is still a need for a higher awa...

Full description

Saved in:
Bibliographic Details
Published in:ChemSusChem 2024-02, Vol.17 (3), p.e202301034-n/a
Main Authors: Basoccu, Francesco, Cuccu, Federico, Porcheddu, Andrea
Format: Article
Language:English
Subjects:
Delivery of Health Care
healthcare
industry
mechanochemistry
Nitrosamine
Nitrosamines
Nutrients
solvent free
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Nitroso derivatives with unique characteristics have been extensively studied in various fields, including biology and clinical research. Although there has been substantial investigation of “nitrosable” components in many drugs and commonly consumed nutrients, there is still a need for a higher awareness about their formation and characterization. This study demonstrates how these derivatives can be produced through a mechanochemical procedure under solid‐state conditions. The results include synthesizing previously unknown compounds with potential biological and pharmaceutical applications, such as a nitrosamine derived from a Diclofenac‐like structure. In a new mechanochemical procedure, a solid source of “nitrosating agents” has been used to synthesize nitroso compounds from amines, alcohols, amides, and ureas without solvents.
ISSN:1864-5631
1864-564X
DOI:10.1002/cssc.202301034