Systemic immunosuppression depletes peripheral blood regulatory B cells in patients with immune thrombocytopenia

Summary Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid naïve ITP patients enrolled in the multicentre FLIGHT trial and found that the numbers of Bregs in their peripheral blood wer...

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Bibliographic Details
Published in:British journal of haematology 2024-02, Vol.204 (2), p.644-648
Main Authors: Stimpson, Madeleine L., Wolf, Julia, Charbit, Bruno, Williams, Emily L., Lait, Philippa J. P., Schewitz‐Bowers, Lauren P., Lee, Richard W. J., Bradbury, Charlotte A.
Format: Article
Language:English
Subjects:
B-Lymphocytes, Regulatory
Bregs
cytokines
Glucocorticoids
Humans
Idiopathic thrombocytopenic purpura
Immunosuppression
Immunosuppression Therapy
ITP
Lymphocytes B
Mycophenolate mofetil
Mycophenolic acid
Peripheral blood
Prospective Studies
Purpura, Thrombocytopenic, Idiopathic
Thrombocytopenia
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Summary:Summary Regulatory B (Breg) cells are potentially implicated in the pathogenesis of immune thrombocytopenia (ITP). We analysed a prospective cohort of newly diagnosed steroid naïve ITP patients enrolled in the multicentre FLIGHT trial and found that the numbers of Bregs in their peripheral blood were similar to healthy controls. In contrast, Breg numbers were significantly reduced in ITP patients treated with systemic immunosuppression (glucocorticoids or mycophenolate mofetil). We also demonstrate that glucocorticoid treatment impairs Breg interleukin‐10 production via an indirect T‐cell‐mediated mechanism.
ISSN:0007-1048
1365-2141
DOI:10.1111/bjh.19144