Colloid and pigmented histiocytes in lymph node aspirates as a clue to metastasis in patients with a history of papillary thyroid carcinoma

Introduction Cystic changes, calcification, colloid material, and multinucleated giant cells are frequently associated with primary and metastatic papillary thyroid carcinoma (PTC). These features are sometimes present in negative lymph node fine‐needle aspiration cytology (FNAC). This study aims to...

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Bibliographic Details
Published in:Diagnostic cytopathology 2024-01, Vol.52 (1), p.22-29
Main Authors: Ng, Joanna K. M., Chan, Amy B. W., Li, Joshua J. X.
Format: Article
Language:English
Subjects:
Calcification
cytology
fine‐needle aspiration
Histology
Lymphatic system
Metastasis
papillary thyroid carcinoma
Thyroid cancer
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Summary:Introduction Cystic changes, calcification, colloid material, and multinucleated giant cells are frequently associated with primary and metastatic papillary thyroid carcinoma (PTC). These features are sometimes present in negative lymph node fine‐needle aspiration cytology (FNAC). This study aims to review nodal aspirates of PTC to elucidate the significance of these cytological features in aspirates without tumor cells. Methods FNAC specimens from patients with PTC confirmed on thyroidectomy were reviewed for cystic changes, tumor‐associated features, and lymphoid components. Histologic follow‐up of the lymph nodes were retrieved for correlation. Results A total of 113 aspirates were retrieved, of which 79 showed tumor cells on the FNAC specimen, and 95 were matched to a positive lymph node histology. At univariable analysis, calcification (n = 18/113, p = .044), colloid material (n = 40/113, p = .001), multinucleated giant cells (n = 29/113, p = .028), tumor cells (n = 79/133, p 
ISSN:8755-1039
1097-0339
DOI:10.1002/dc.25236