The Expanding Role of HLA Gene Tests for Predicting Drug Side Effects

Adverse drug reactions can be either dose-dependent (Type A) or idiosyncratic (Type B). Type B adverse drug reactions tend to be extremely rare and difficult to predict. They are usually immune-mediated. Examples include severe skin reactions and drug-induced liver injury. For many commonly prescrib...

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Bibliographic Details
Published in:The American journal of the medical sciences 2024-01, Vol.367 (1), p.14-20
Main Authors: Petry, Natasha, Forest, Kennedy, Wilke, Russell A.
Format: Article
Language:English
Subjects:
adverse drug reaction
Anti-Bacterial Agents
Chemical and Drug Induced Liver Injury - etiology
Chemical and Drug Induced Liver Injury - genetics
decision support
Drug-Related Side Effects and Adverse Reactions - diagnosis
Drug-Related Side Effects and Adverse Reactions - genetics
HLA Antigens - genetics
HLA Antigens - pharmacology
Humans
pharmacogenetics
Skin
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Summary:Adverse drug reactions can be either dose-dependent (Type A) or idiosyncratic (Type B). Type B adverse drug reactions tend to be extremely rare and difficult to predict. They are usually immune-mediated. Examples include severe skin reactions and drug-induced liver injury. For many commonly prescribed drugs (such as antibiotics), the risk of developing an idiosyncratic adverse drug reaction is influenced by variability in the human leukocyte antigen (HLA) genes. Because these HLA-mediated adverse drug reactions can be lethal, there is growing interest in defining which specific drug-gene relationships might benefit from pre-emptive HLA genotyping and automated clinical decision support. This review summarizes the literature for HLA-mediated adverse reactions linked to common drugs.
ISSN:0002-9629
1538-2990
1538-2990
DOI:10.1016/j.amjms.2023.10.004