Vitamin D Serum Levels and Vitamin D Receptor Genotype in Patients with Parkinson’s Disease

•Higher prevalence of vitamin D deficiency was demonstrated in PD patients compared to control subjects.•Severity and stage of Parkinson’s disease were significantly associated with lower 25OHD concentration.•A higher frequency of G allele of CYP2R1 polymorphism was observed in all subgroups with vi...

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Published in:Neuroscience 2023-11, Vol.533, p.53-62
Main Authors: Džoljić, Eleonora, Matutinović, Marija Sarić, Stojković, Oliver, Veličković, Jelena, Milinković, Neda, Kostić, Vladimir, Ignjatović, Svetlana
Format: Article
Language:English
Subjects:
25(OH)-vitamin D
Parkinson’s disease
vitamin D
vitamin D deficiency
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Summary:•Higher prevalence of vitamin D deficiency was demonstrated in PD patients compared to control subjects.•Severity and stage of Parkinson’s disease were significantly associated with lower 25OHD concentration.•A higher frequency of G allele of CYP2R1 polymorphism was observed in all subgroups with vitamin D deficiency. Vitamin D is a steroid hormone, known to be involved in the pathogenesis of various neurodegenerative disorders, including Parkinson’s disease (PD). We aimed to clarify the relationship between hypovitaminosis D and the predisposition for PD and its clinical presentation. An additional aim was to examine the specific gene polymorphisms associated with vitamin D level. Total level of 25(OH)-vitamin D (25(OH)D) was measured in the serum of parkinsonian patients (n = 113) and controls (n = 82) using a commercial immunoassay. Genetic analyses were performed using Taqman assays on Real Time PCR amplification system. Higher frequency of vitamin D deficiency (
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2023.10.004